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Cyclerion Therapeutics

Cyclerion Therapeutics logo
🇺🇸United States
Ownership
Public
Employees
1
Market Cap
$6.9M
Website
http://www.cyclerion.com
Introduction

Cyclerion Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of human therapeutics. Its product pipeline includes several sGC stimulators, small molecules that act synergistically with nitric oxide on sGC to boost production of cyclic guanosine monophosphate. The company was founded on September 6, 2018 and is headquartered in Cambridge, MA.

Clinical Trials

15

Active:1
Completed:13

Trial Phases

2 Phases

Phase 1:8
Phase 2:5

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (13 trials with phase data)• Click on a phase to view related trials

Phase 1
8 (61.5%)
Phase 2
5 (38.5%)

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2019-03-27
Last Posted Date
2019-07-15
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
24
Registration Number
NCT03892499
Locations
🇺🇸

PPD, Austin, Texas, United States

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: [14C]-praliciguat
First Posted Date
2019-01-28
Last Posted Date
2019-06-19
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
8
Registration Number
NCT03818295
Locations
🇺🇸

Covance Clinical Research Unit Inc., Madison, Wisconsin, United States

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Olinciguat in Healthy Male Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: [14C]-olinciguat
First Posted Date
2019-01-07
Last Posted Date
2019-04-03
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
8
Registration Number
NCT03795519
Locations
🇺🇸

Covance Clinical Research Unit Inc., Madison, Wisconsin, United States

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
First Posted Date
2018-04-17
Last Posted Date
2019-04-03
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
24
Registration Number
NCT03499106
Locations
🇺🇸

IQVIA, Overland Park, Kansas, United States

A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)

Phase 2
Completed
Conditions
Sickle Cell Disease
Interventions
Drug: Placebo
First Posted Date
2017-09-15
Last Posted Date
2023-07-21
Lead Sponsor
Cyclerion Therapeutics
Target Recruit Count
88
Registration Number
NCT03285178
Locations
🇺🇸

Children's Hospital of Orange County, Orange, California, United States

🇺🇸

MedStar Health Research Institute, MedStar Washington Hospital Center, Washington, District of Columbia, United States

🇺🇸

Howard University Center for Sickle Cell Disease, Washington, District of Columbia, United States

and more 34 locations
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