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Clinical Trials/NCT03212898
NCT03212898
Completed
Not Applicable

The Influence of Pharmacist Interventions on the Effectiveness of Warfarin Treatment in Elderly Patients From Rural Areas

Slaven Falamić0 sites131 target enrollmentMay 2015

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Atrial Fibrillation
Sponsor
Slaven Falamić
Enrollment
131
Primary Endpoint
Time in therapeutic range (TTR)
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

The primary study goal is to explore the influence of pharmacist interventions on the effectiveness of warfarin treatment in a specific subpopulation.

Registry
clinicaltrials.gov
Start Date
May 2015
End Date
January 2017
Last Updated
8 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Slaven Falamić
Responsible Party
Sponsor Investigator
Principal Investigator

Slaven Falamić

Slaven Falamić,MPharm, Prinicipal-Investigator

Slaven Falamić

Eligibility Criteria

Inclusion Criteria

  • Age ≥65 years
  • Living site of participant outside the city eg. rural site
  • Expected duration of warfarin therapy at least 6 months from the inclusion in the study and 3 months before

Exclusion Criteria

  • Hospitalization
  • Vegetarianism
  • Patients not able to provide an informed consent
  • The use of drug that has an X level of clinical significance of interaction with warfarin according to Lexicomp interact base

Outcomes

Primary Outcomes

Time in therapeutic range (TTR)

Time Frame: 6 months

Time in therapeutic range by Rosendaal method (percentage of time in therapeutic range)

Secondary Outcomes

  • Adverse drug reactions(6 months)
  • Adherence(6 months)
  • International randomised ratio(6 months)
  • Quality of life(6 months)
  • Acceptance of pharmacist's intervention by the general practitioners(6 months)
  • Time to adverse drug reaction(6 months)
  • Dietary intake of vitamin K(6 months)
  • Incidence and influence of clinically significant drug interactions(6 months)

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