Effects of Crossover Point Exercise on Vascular Function of Women in Different Menopausal Years
- Conditions
- Vascular Health
- Interventions
- Other: COP exercise
- Registration Number
- NCT06201312
- Lead Sponsor
- Beijing Sport University
- Brief Summary
Recruit postmenopausal women and randomly assign them to one of four groups: Early Postmenopausal Exercise Group (EE), Late Postmenopausal Exercise Group (LE), Early Postmenopausal Control Group (EC), and Late Postmenopausal Control Group (LC).
All participates will undergo a graded exercise test to determine their maximum oxygen uptake, and vascular function response will be measured immediately after the exercise test. The COP exercise intensity for postmenopausal women will be obtained through the exercise test, and subjects in the EE and LE groups will undergo exercise training at this intensity for a period of three months. Tests and analyses of relevant indicators will be conducted on subjects in all four groups before and after the intervention. The exercise load experiments will be performed on a cycle ergometer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 120
- Postmenopausal women without cardiovascular disease
- Women with undetermined menopause
- BMI <18.5 kg/m2 or BMI >28 kg/m2
- fasting plasma triglyceride levels ≥500 mgdl
- diabetes mellitus or fasting glucose >140 mgd
- blood creatinine >2.0 mgdl
- uncontrolled hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >110 mmHg)
- untreated thyroid disease
- life-threatening illness with a prognosis of <5 years;
- history of deep vein thrombosis,
- pulmonary embolism, or breast cancer;
- currently receiving estrogen therapy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Early Postmenopausal Exercise Group (EE) COP exercise - Late Postmenopausal Exercise Group (LE) COP exercise -
- Primary Outcome Measures
Name Time Method Brachial-Ankle Pulse Wave Velocity 12 weeks The change of Brachial-Ankle Pulse Wave Velocity before and after intervention.
Ankle-Brachial Index 12 weeks The change of Ankle-Brachial Index before and after intervention.
Carotid Intima-Media Thickness 12 weeks The change of Carotid Intima-Media Thickness before and after intervention.
Resistive Index 12 weeks The change of Resistive Index before and after intervention
Carotid Diameter 12 weeks The change of Carotid Diameter before and after intervention.
Brachial Artery Flow-Mediated Dilation 12 weeks The changes in brachial artery flow-mediated dilation are assessed at three time points: before the intervention, after the acute exercise, and three months following the intervention.
Carotid End-Diastolic Velocity 12 weeks The change of Carotid End-Diastolic Velocity before and after intervention.
Carotid Peak Systolic Velocity 12 weeks The change of Carotid Peak Systolic Velocity before and after intervention.
Pulsatility Index 12 weeks The change of Pulsatility Index before and after intervention.
- Secondary Outcome Measures
Name Time Method ERα Protein Expression level 12 weeks The change of Protein Expression before and after intervention
Plasma Nitrate level 12 weeks The change of plasma nitrate before and after intervention.
PGC1α mRNA Expression level 12 weeks The change of PGC1α mRNA Expression before and after intervention
p38MAPK Protein Expression level 12 weeks The change of p38MAPK Protein Expression before and after intervention
Oxidized Glutathione level 12 weeks The change of Oxidized Glutathione before and after intervention
Serum Soluble Vascular Cell Adhesion Molecule-1 level 12 weeks The change of Serum Soluble Vascular Cell Adhesion Molecule-1 Expression before and after intervention
Serum Nitric Oxide level 12 weeks The change of serum nitric oxide before and after intervention.
ERRα mRNA and Protein Expression level 12 weeks The change of ERRα mRNA and Protein Expression before and after intervention.
ERα mRNA Expression level 12 weeks The change of ERα mRNA Expression before and after intervention
Low-Density Lipoprotein Cholesterol level 12 weeks The change of Low-Density Lipoprotein Cholesterol before and after intervention
Calculate GSSG/GSH Ratio 12 weeks The change of Calculate GSSG/GSH Ratio before and after intervention
body weight 12 weeks The change of body weight before and after intervention
Triglycerides level 12 weeks The change of Triglycerides before and after intervention
PGC1α Protein Expression level 12 weeks The change of PGC1α Protein Expression before and after intervention
p38MAPK mRNA Expression level 12 weeks The change of p38MAPK mRNA Expression before and after intervention
Total Cholesterol level 12 weeks The change of Total Cholesterol before and after intervention
High-Density Lipoprotein Cholesterol level 12 weeks The change of High-Density Lipoprotein Cholesterol before and after intervention
Lipoprotein(a) level 12 weeks The change of Lipoprotein(a) before and after intervention
Heart Rate 12 weeks The change of Heart Rate before and after intervention
Ratio of Early to Atrial Diastolic Mitral Inflow Velocity 12 weeks The change of Ratio of Early to Atrial Diastolic Mitral Inflow Velocity before and after intervention
NT-proBNP level 12 weeks The change of NT-proBNP before and after intervention
Apolipoprotein B level 12 weeks The change of Apolipoprotein B before and after intervention
Vascular Endothelial Growth Factor level 12 weeks The change of Vascular Endothelial Growth Factor before and after intervention
Apolipoprotein AI level 12 weeks The change of Apolipoprotein AI before and after intervention
Interventricular Septum Thickness in Systole 12 weeks The change of Interventricular Septum Thickness in Systole before and after intervention
Cardiac Output 12 weeks The change of Cardiac Output before and after intervention
Serum Reduced Glutathione level 12 weeks The change of Serum Reduced Glutathione before and after intervention
Soluble Intercellular Adhesion Molecule-1 level 12 weeks The change of Soluble Intercellular Adhesion Molecule-1 before and after intervention
Left Ventricular End-Systolic Diameter 12 weeks The change of Left Ventricular End-Systolic Diameter before and after intervention
Left Ventricular End-Diastolic Diameter 12 weeks The change of Left Ventricular End-Diastolic Diameter before and after intervention
Left Ventricular Posterior Wall Thickness in Diastole 12 weeks The change of Left Ventricular Posterior Wall Thickness in Diastole before and after intervention
Left Ventricular End-Diastolic Volume 12 weeks The change of Left Ventricular End-Diastolic Volume before and after intervention
Early Diastolic Mitral Inflow Velocity 12 weeks The change of Early Diastolic Mitral Inflow Velocity before and after intervention
body mass index 12 weeks The change of body mass index before and after intervention
Interleukin 6 level 12 weeks The change of Interleukin 6 before and after intervention
Estradiol level 12 weeks The change of Estradiol before and after intervention
Interventricular Septum Thickness in Diastole 12 weeks The change of Interventricular Septum Thickness in Diastole before and after intervention
Left Ventricular Ejection Fraction 12 weeks The change of Left Ventricular Ejection Fraction before and after intervention
Stroke Volume 12 weeks The change of Stroke Volume before and after intervention
Atrial Diastolic Mitral Inflow Velocity 12 weeks The change of Atrial Diastolic Mitral Inflow Velocity before and after intervention
Left Ventricular Posterior Wall Thickness in Systole 12 weeks The change of Left Ventricular Posterior Wall Thickness in Systole before and after intervention
Left Ventricular End-Systolic Volume 12 weeks The change of Left Ventricular End-Systolic Volume before and after intervention
Fractional Shortening 12 weeks The change of Fractional Shortening before and after intervention
Trial Locations
- Locations (1)
School of Sports Medicine and Rehabilitation, Beijing Sport University
🇨🇳Beijing, China