Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.

Not Applicable

• Conditions: Health-Related Behavior

• Registration Number: NCT06678386
• Lead Sponsor: Mahidol University

Brief Summary

The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:

* Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks?

* How does sweet intensity change after completing dietary modification for 8 weeks?

* Does individual daily sugar intake change after completing dietary modification for 8 weeks?

Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity.

Participants will:

* Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks.

* Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires.

* Keep a diet record for a total of 15 days during the research period.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-10-01
• Status Verified: 2024-11
• Study First Submitted: 2024-11-06
• Study First Submitted QC: 2024-11-06
• Last Update Submitted: 2024-11-06
• Study First Posted: 2024-11-07
• Last Update Posted: 2024-11-07
• Primary Completion: 2025-03-31
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
• People who score 10 or more points on the sweet food consumption behavior questionnaire.
• People who are able to communicate in the Thai language.
• People who are able to chat and use video calls via the Line application.
• People who agree to modify their diet and beverages according to the recommendations of a dietitian.
• People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire.

Exclusion Criteria

• People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
• People with a history of severe illness in the past 6 months.
• People who regularly use medication, excluding contraceptives and vitamins.
• Pregnant women.
• People who have experienced a weight change of at least 10% over the past 3 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Sweet intensity change from baseline after 12 weeks of the intervention.	16 weeks from baseline (12 weeks after the start of the intervention)	Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.

Secondary Outcome Measures

Name	Time	Method
Sweet intensity change from baseline after completing the intervention for 8 weeks.	24 weeks from baseline	Percentage of participants whose sweet intensity increased after completing dietary modification for 8 weeks, compared to those with an unmodified diet.
Changes in sugar consumption behavior from baseline	24 weeks from baseline	The average daily caloric intake from sugars after completing dietary modification for 8 weeks, compared to before the dietary change.

Trial Locations

Locations (1)

Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkoknoi, Bangkok, Thailand