Investigating the impact of autologous fat grafting on the risk of oesophageal strictures post endoscopic resection: a pilot study

Not Applicable

• Conditions: Squamous cell oesophageal dysplasia; Barrett’s oesophagus with dysplasia; intramucosal oesophageal cancer; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Surgery - Surgical techniques; Cancer - Head and neck

• Registration Number: ACTRN12622001249741
• Lead Sponsor: St Vincent's Hospital Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-09-16
• Last Update Posted: 26 September 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1.Aged 18 years old and over
2.Medically fit for anaesthesia
3.Squamous cell or Barrett’s oesophagus with dysplasia or intramucosal cancer
4.75% or greater oesophageal circumferential resection either via Endoscopic Mucosal Resection (EMR) or Endoscopic Submucosal Resection (ESD)
5.Informed consent obtained from the patient or legal representative

Exclusion Criteria

1. Pregnant at enrolment
2. Unable to obtain informed consent from the patient or legal representative
3. Medically unfit for anaesthesia
4. Current smokers
5. Previous radiotherapy to the involved oesophagus
6. Irreversible coagulopathy: INR >1.5
7. Irreversible thrombocytopenia: platelet count <50 x 109/L, thrombocytopenia confirmed by manual count
8. Dual antiplatelet therapy or therapeutic anticoagulation that cannot be withheld for the procedure
9. Presence of oesophageal varices
10. Immunocompromised

Study & Design

• Study Type: Interventional
• Study Design: Not specified