Reducing antiepileptic medication during a multiple-day video-EEG to investigate the feasibility of epilepsy surgery: what is the best way (safest and most efficious) to reduce antiepileptic drugs?
Recruiting
- Conditions
- Epilepsy, epilepsy surgery
- Registration Number
- NL-OMON22478
- Lead Sponsor
- niverstiy Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 850
Inclusion Criteria
Long-term video-EEG monitoring (LTM) is initiated in the evaluation for epilepsy surgery (all ages)
- Informed consent signed. In case of age below 16, both parents sign informed consent. For the ages 12-15 (by Dutch law, may be different per country), the child and both parents sign. If they do not, the patient will not participate.
Exclusion Criteria
-intracranial long-term monitoring (subdural grid or depth/stereo-EEG)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Predictors of efficacy: A sufficient number of habitual seizures have been recorded. <br /><br>Predictors of safety: presence of complications, defined as any of the following: status epilepticus (defined as a seizure lasting ¡Ý 5 minutes), seizure clustering (¡Ý 3 seizures in 4 hours), falls and physical injuries, postictal psychosis, generalized tonic-clonic seizures in patients without prior occurrence of these, cardio-respiratory distress, or acute medical complications requiring intervention
- Secondary Outcome Measures
Name Time Method - The proportion of patients with AED tapering.<br /><br>- Baseline differences between patients with and patients without AED tapering<br /><br>- Efficacy comparison between patients with and patients without AED tapering<br /><br>- Safety comparison between patients with and patients without AED tapering<br /><br>- Effects of AED withdrawal and restart of AEDs on seizure frequency and cognitive and emotional functioning in the weeks after LTM