The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men

Not Applicable

Completed

• Conditions: Cardiovascular Status; Hepatic Fatty Acid Metabolism; Systemic Insulin Resistance; Oxidative Stress
• Interventions: Dietary Supplement: high sugar diet

• Registration Number: NCT01050140
• Lead Sponsor: University of Nottingham

Brief Summary

Dietary consumption of fructose has increased by nearly 50% since 1960.

A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.

Detailed Description

The protocol will assess the following outcomes:

1. The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet

2. The effect of a high fructose vs. glucose diet on liver ATP stores

3. The effect of a high fructose vs. glucose diet on markers of oxidative stress

4. The effect of a high fructose vs. glucose diet on cardiovascular status

Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.

32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.

The sugars will first be taken in an energy balanced and then an overfeeding setting.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2010-01-14
• Study First Submitted QC: 2010-01-14
• Study First Posted: 2010-01-15
• Primary Completion: 2010-12
• Study Completion: 2011-04
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-03
• Last Update Posted: 2012-07-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

1. Body mass index 25-32
2. Waist > hip circumference
3. Age 18-50 years
4. Male

Exclusion Criteria

1. Reported weight change > 3 kg in prior 3/12
2. Active health problems
3. Contraindications to MRI scanning
4. Symptoms of functional bloating or irritable bowel syndrome
5. Abnormal liver or renal function tests
6. Random glucose greater than 11.0 mmol/L
7. Evidence of metabolic or viral liver disease as screened for by hepatitis B and C serology, and ferritin.
8. Alcohol intake > 21 units per week
9. Vegetarianism
10. Normal daily fructose intake from drinks greater than that in 500ml of coca cola
11. Abnormal carbohydrate energy contribution to baseline diet - defined as greater than 2 standard deviations from the mean of the National Diet and Nutrition Survey 2002 data

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
glucose	high sugar diet	25% dietary energy from glucose
fructose	high sugar diet	25% dietary energy from fructose

Primary Outcome Measures

Name	Time	Method
Liver triglyceride content	2 weeks

Secondary Outcome Measures

Name	Time	Method
Liver ATP, PME concentration and pH (31P MRS)	2 weeks
Hepatic and systemic insulin resistance	2 weeks
Cardiovascular measures using finometry	2 weeks
Muscle triglyceride content	2 weeks
Total abdominal visceral fat content (MRI)	2 weeks
Liver de novo lipogenesis	2 weeks
Resting energy expenditure, lipid and carbohydrate oxidation rates	2 weeks
Systemic oxidative stress and inflammatory cytokine profile	2 weeks

Trial Locations

Locations (1)

School of Biomedical Sciences, University of Nottingham; 🇬🇧 Nottingham, Nottinghamshire, United Kingdom