Can Advanced-Platelet Rich Fibrin (A-PRF), a patient blood-derived living biomaterial, prevent chronic inflammation after wisdom tooth surgery?

Not Applicable

• Conditions: Systemic acute inflammatory response after wisdom tooth removal in otherwise healthy patients; Oral Health; Systemic Inflammatory Response Syndrome of non-infectious origin without organ failure

• Registration Number: ISRCTN12738881
• Lead Sponsor: niversity of Santiago de Compostela

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-12-16
• Last Update Posted: 5 January 2021
• Study Completion: 2021-04-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Two unilateral fully impacted mandibular third molars which have the same degree of surgical difficulty comparing one side with the other
2. Healthy patients without significant medical diseases or a history of bleeding problems
3. Adequate level of plaque control (plaque index (PI) <15%)
4. Non-smokers patients
5. Able to give written consent

Exclusion Criteria

1. Younger than 18 years old or older than 65 years old
2. Females who were pregnant or lactating
3. Females using contraceptive methods
4. Had any reported systemic illness
5. Had chronic use of any medication within 30 d prior to the study inclusion
6. Affected by periodontitis (Tonetti, Greenwell, & Kornman, 2018)
7. Signs of pericoronitis
8. Removable upper and/or lower partial dentures
9. Had periapical and periradicular radiolucencies that were detected on X-rays

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute inflammatory response measured by hs-C-reactive protein serum levels at 24 h after intervention

Secondary Outcome Measures

Name	Time	Method
There are no secondary outcome measures