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Clinical Trials/NCT06442631
NCT06442631
Not yet recruiting
Not Applicable

An Individualized Video-based Stroke Education Platform for Stroke Survivors and Caregivers

University of Pennsylvania10 sites in 1 country690 target enrollmentMarch 1, 2026

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stroke, Acute
Sponsor
University of Pennsylvania
Enrollment
690
Locations
10
Primary Endpoint
The Stroke Patient Education Retention (SPER) survey
Status
Not yet recruiting
Last Updated
3 months ago

Overview

Brief Summary

The goal of this multicenter randomized trial is to evaluate the impact of a personalized video-based stroke education platform on patient-centered and health system-centered outcomes. The main questions this study aims to address are:

  1. Does a personalized, video-based educational platform improve stroke knowledge?
  2. Does a personalized, video-based educational platform reduce post-discharge health system utilization?
  3. Do different strategies of nudging improve engagement with educational material after hospital discharge?

In order to determine the effect of this personalized stroke education strategy, researchers will compare subjects who receive standard stroke education with those who receive the personalized stroke education platform in addition to standard standard education. Patient knowledge will be assessed 90-days after discharge. Study participants will include both stroke patients and caregivers, who will:

  1. Receive standard education during the stroke hospitalization
  2. Complete a survey on the day of hospital discharge to assess their baseline knowledge.
  3. Half of the subjects will be randomly assigned to also receive access to the personalized stroke education platform on the day of discharge.
  4. All subjects will complete two follow-up study visits (7 and 90 days after discharge) in order to complete surveys.

Detailed Description

Stroke education represents a unique opportunity to empower stroke survivors (and caregivers) to promote self-management, augment adherence, and reduce post-stroke healthcare utilization. Despite being a key quality metric for stroke centers, most patient and caregiver education is poorly retained and a common source of dissatisfaction. In fact, most survivors are unaware of the cause of their stroke, their modifiable risk factors, and how to properly respond to future stroke symptoms. Although there is no gold standard, most centers rely on a combination of bedside verbal communication and standardized printed materials. Prior work has clarified that effective and durable educational interventions benefit from engaging content, personalization, accessibility, and low cost/burden. Retention is very poor during the stroke hospitalization, but this can be overcome by promoting ongoing engagement after discharge. To that end, our group developed a web-based educational platform (MyStroke) that leverages the electronic health record to personalize video-based educational content for each stroke survivor. Simple but engaging videos are curated to address each patient's stroke etiology, individualized risk factors, prescribed stroke prevention medications, and post-stroke lifestyle issues. This approach transforms point-of-care stroke education, and integrated nudges reveal opportunities for re-education and re-engagement after hospital discharge to achieve a durable impact. In a recent single-center pilot trial, MyStroke improved patient and caregiver satisfaction and improved key elements of stroke knowledge. The objective of this proposal is to build upon our encouraging preliminary experience and conduct a multicenter randomized trial to evaluate the impact of MyStroke on both patient-centered (stroke knowledge, self-efficacy, satisfaction, quality of life) and health system-centered outcomes (medication adherence and health system utilization). Electronic nudges will leverage principles of behavioral economics (i.e. enhanced nudges) to promote ongoing engagement. Our preliminary data indicate that even bland nudges promote engagement, but here we propose to use both bland nudges and enhanced nudges, such that platform analytics will compare the influence of different nudge types. Use of technology in this context stands to bridge geographic distances, connect stakeholders, and increase access to information, but it important to recognize the potential to exacerbate inequities for elderly patients and those with limited access to technology. Issues of digital inclusivity will be evaluated to reveal opportunities for platform improvement. The MyStroke platform offers a scalable solution stroke education which imposes no burden on the clinical team due to its reliance on a limited number of input fields which can be harvested from the electronic health record to individualized content for each patient.

Registry
clinicaltrials.gov
Start Date
March 1, 2026
End Date
March 1, 2030
Last Updated
3 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Christopher Favilla

Assistant Professor of Neurology at the University of Pennsylvania

University of Pennsylvania

Eligibility Criteria

Inclusion Criteria

  • At least 18 years old
  • Admitted to hospital with clinical diagnosis of acute ischemic stroke (imaging confirmation not required)
  • Stroke symptom onset within 30 days of enrollment
  • Being discharged to either home or an acute rehabilitation facility
  • Access to internet enabled device (smartphone, tablet, computer)
  • Fluent in either English or Spanish (does not need to be native or primary language)
  • Willingness and ability to sign informed consent

Exclusion Criteria

  • Severe aphasia (score of ≥2 on NIHSS item 9)
  • Ischemic stroke that is attributed to a surgical procedure
  • Resides in a skilled nursing facility prior to admission
  • Being discharged to skilled nursing facility or long-term acute care facility
  • Unwillingness or inability to participate in remote/virtual study visits
  • A terminal or advanced condition that raises the possibility the subject may not survive 90 days
  • Any other illness or condition that the investigator feels would pose a hazard to the subject from participation in the study

Outcomes

Primary Outcomes

The Stroke Patient Education Retention (SPER) survey

Time Frame: 90 days

Total score from the 5-question SPER (scale 0-10; higher score reflects better knowledge)

Secondary Outcomes

  • Emergency Department utilization(90 days)
  • Stroke risk factor awareness(90 days)
  • Urgent outpatient visits(90 days)
  • Outpatient provider communication(90 days)
  • Antithrombotic medication awareness(90 days)
  • Stroke Self-Efficacy Questionnaire (SSEQ)(90 days)
  • Medication adherence(90 days)
  • Patient satisfaction with stroke education(90 days)
  • Stroke etiology awareness(90 days)
  • EuroQoL EQ-5D-5L(90 days)

Study Sites (10)

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