Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse
- Conditions
- Pelvic Organ Prolapse
- Registration Number
- NCT03748693
- Lead Sponsor
- Hillel Yaffe Medical Center
- Brief Summary
The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls.
We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
- Women with POP undergoing colporrhaphy
- Women undergoing hysterectomy
Exclusion Criteria
- Autoimmune and connective tissue disorders
- Cancer in genital tract
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immune response in POP Two weeks Tissue biopsy will analyzed for IMC and compared to control group
Cytokine environment in POP Two weeks Tissue biopsy will analyzed for cytokine environment and compared to control group
- Secondary Outcome Measures
Name Time Method