NCT03748693Unknown不适用
Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- Immune response in POP
研究概览
简要总结
The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls.
We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women with POP undergoing colporrhaphy
- •Women undergoing hysterectomy
排除标准
- •Autoimmune and connective tissue disorders
- •Cancer in genital tract
结局指标
主要结局
Immune response in POP
时间窗: Two weeks
Tissue biopsy will analyzed for IMC and compared to control group
Cytokine environment in POP
时间窗: Two weeks
Tissue biopsy will analyzed for cytokine environment and compared to control group
次要结局
未报告次要终点
研究者
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