eurofeedback training of frontostriatal control circuits for modification of obsessive-compulsive symptoms in psychiatric diseases
Phase 3
Recruiting
- Conditions
- F42Obsessive-compulsive disorder
- Registration Number
- DRKS00021097
- Lead Sponsor
- START Programm der Medizinischen Fakultät RWTH Aachen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age: 18 - 55 years,
- good knowledge of German
- affected by a psychiatric illness requiring psychiatric treatment (a primary diagnosis of an obsessive-compulsive disorder is not required)
- currently under treatment for obsessive thoughts and/or actions
- Y-BOCS Score = 16
- Stable treatment regime at least four weeks before the start of the neurofeedback experiment
Exclusion Criteria
- Pregnancy or lactation,
- Contraindications - also relative- to MR examinations such as magnetic metal implants, large tattoos or claustrophobia,
- non-existent or limited ability of the participant to give consent,
- Drug addiction,
- acute conditions requiring inpatient treatment.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical improvement of symptoms measured by YBOCS (Yale-Brown Obsessive-Compulsive Scale).
- Secondary Outcome Measures
Name Time Method Change in connectivity between ACC and vStr in neurofeedback training (changes from baseline connectivity).<br><br>Alteration of brain activation in the resting state<br>(Resting state fMRI as a measure before and after neurofeedback)<br><br>Change in pathology (quality of life)<br>WHOQOL-BREF questionnaire as a measure of quality of life before and after NF training and after 4 weeks (follow-up).<br><br>Change in pathology (depression) <br>BDI-II as measure of intensity and quality of depressive symptoms before NF training and after 4 weeks (follow-up)