Bupivacaine With Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block in Caesarean Section

Not Applicable

Completed

• Conditions: Post Operative Pain
• Interventions: Procedure: Transversus Abdominis Plane Block with bupivacain Plus dexamethasone; Procedure: Transversus Abdominis Plane Block with bupivacain

• Registration Number: NCT06292273
• Lead Sponsor: Menoufia University

Brief Summary

Transversus Abdominis plane (TAP) block is a regional technique for providing analgesia of the anterolateral abdominal wall. TAP block are commonly given in patients who have undergone various abdominal as well as pelvic surgeries such as caesarean section, hysterectomy, appendicectomy and various laparoscopic surgeries. this study is conducted to analyse the effect of addition of dexmedetomidine to bupivacaine in Transversus Abdominis Plane (TAP) block.

Detailed Description

Peripheral nerve block is becoming increasingly popular technique for postoperative pain relief and is also established as a part of multimodal analgesia and enhanced recovery program. Transversus abdominis plane (TAP) block is a regional technique for providing analgesia of the anterolateral abdominal wall. TAP block are commonly given in patients who have undergone various abdominal as well as pelvic surgeries such as caesarean section, hysterectomy, appendicectomy and various laparoscopic surgeries.The Purpose of a TAP block is to infiltrate local anaesthetic agents in the plane between the internal oblique and transversus abdominis muscles thereby providing effective postoperative analgesia. Earlier the blind TAP block (through lumbar triangle of Petit) was commonly given but with widespread use of ultrasound nowadays it is almost always given under ultrasound guidance. Accuracy and efficacy of TAP block is significantly improved under ultrasound guidance because under ultrasound guidance the anesthetic agent can be properly deposited in the neurovascular plane. Ultrasound provides real time and direct visualisation of needle during infiltration of local anaesthetic drug.

Study Timeline

• Study Start: 2023-10-10
• Primary Completion: 2024-02-01
• Study Completion: 2024-02-20
• Study First Submitted: 2024-02-21
• Status Verified: 2024-03
• Study First Submitted QC: 2024-03-02
• Last Update Submitted: 2024-03-02
• Study First Posted: 2024-03-05
• Last Update Posted: 2024-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• pregnant female elected for cesarean section
• ASAll

Exclusion Criteria

• coagulopathy

• BMI>35

  • heart Diseases
  • diabets

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group Bupivacain Plus dexamethasone	Transversus Abdominis Plane Block with bupivacain Plus dexamethasone	receiving plain bupivacaine 0.1%, 35 ml with dexmedetomidine 0.5
Group bupivacain	Transversus Abdominis Plane Block with bupivacain	plain bupivacaine 0.25%, 25 ml bilaterally

Primary Outcome Measures

Name	Time	Method
Post operative pain	24 hours	visual analog score from 0 to 10 where 0 is no pain and 10 worst pain ever

Secondary Outcome Measures

Name	Time	Method
Total analgesic consumption	24 hours	Mg
Side effects	24hours	Nausea, vomiting, pruritus
Heart rate	24 hours	pulse/ min
Sedation	24 hours	Modefied Ramsey sedation score from 1 to 6

Trial Locations

Locations (1)

Faculty of Medicine Menoufia University; 🇪🇬 Cairo, Governorate, Egypt