Optimizing Music-Based Interventions for Stroke
- Conditions
- Stroke
- Interventions
- Behavioral: Music Playing Task
- Registration Number
- NCT06215703
- Lead Sponsor
- NYU Langone Health
- Brief Summary
This study will enroll stroke patients and healthy participants. Participants will complete baseline measures followed by a music playing task during fMRI and simultaneous measurement of motor response using electromyography (EMG) and accelerometry and affective response using electrodermal activity (EDA) and self-reports. The music task consists of tapping an MRI-compatible MIDI drum with either: (1) improvisation or maintaining the beat and (2) live or recorded piano accompaniment. The primary objectives are to identify the motor, affective, and neural outcomes of improvisation and live accompaniment in music playing tasks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
For participants with stroke, to be eligible to participate in this study, an individual must meet all the following criteria:
- hemiparesis resulting from a stroke (ischemic or hemorrhagic) at least 6 months before the enrollment into the study
- age from 18 to 89 years
- ability to move the wrist flexor and extensor muscles without help from the healthy side, scoring above 3 on the Medical Research Council (MRC) Scale for Muscle Strength, reflecting active movement against gravity
- no more than mild resistance to passive movement in the wrist extensor muscle - as demonstrated by a score <2 on the Ashworth Scale (Brashear et al.., 2002)
- a modified Rankin Scale (mRS) < 3 indicating moderate to mild disability and the ability to ambulate independently (Bonita & Beaglehole, 1988)
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
For neurologically normal control (NC) participants, to be eligible to participate in this study, an individual must meet all the following criteria:
- be matched for age, gender, and socioeconomic status (education level) to a previously enrolled participant with stroke
- age from 18 to 89 years
- no history of neurological injury
- ability to comprehend language and provide informed consent
- consenting to participate and willingness to complete MRI testing procedures
- history of neurological injury other than stroke
- moderate to severe depression symptoms indicated by a score >10 on the Patient Health Questionnaire - 9 (PHQ-9; Koenke et al., 2001; Williams et al., 2005)
- visual impairment unable to be corrected with glasses/contact lenses sufficient to allow reading comprehension
- actively performing or practicing a musical instrument more than 2 hours/week
- musical anhedonia indicated by a score < 65 on the Barcelona Music Reward Questionnaire (BMRQ; Mas-Herrero et al., 2013)
- amusia as measured by the Montreal Battery of the Evaluation of Amusia (MBEA; Peretz et al., 2003)
- not being compatible with MRI testing, including having implanted devices, previous exposure to metallic fragments, large tattoos, claustrophobia, and pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Order 4 Music Playing Task Participants randomized to Order 3 will complete the four music playing tasks in the following order: (1) Improvisation, live accompaniment; (2) No improvisation (maintain beat), live accompaniment; (3) Improvisation, no live accompaniment (recorded accompaniment); (4) No improvisation (maintain beat), no live accompaniment (recorded accompaniment). Order 3 Music Playing Task Participants randomized to Order 3 will complete the four music playing tasks in the following order: (1) No improvisation (maintain beat), live accompaniment; (2) Improvisation, live accompaniment; (3) No improvisation (maintain beat), no live accompaniment (recorded accompaniment); (4) Improvisation, no live accompaniment (recorded accompaniment). Order 1 Music Playing Task Participants randomized to Order 1 will complete the four music playing tasks in the following order: (1) No improvisation (maintain beat), no live accompaniment (recorded accompaniment); (2) Improvisation, no live accompaniment (recorded accompaniment); (3) No Improvisation (maintain beat), live accompaniment; (4) Improvisation, live accompaniment. Order 2 Music Playing Task Participants randomized to Order 2 will complete the four music playing tasks in the following order: (1) Improvisation, no live accompaniment (recorded accompaniment); (2) No improvisation (maintain beat), no live accompaniment (recorded accompaniment); (3) Improvisation, live accompaniment; (4) No improvisation (maintain beat), live accompaniment.
- Primary Outcome Measures
Name Time Method Total Acceleration of Hand Movements during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using an MRI-compatible accelerometer attached to the hand with a Velcro strap.
Total Acceleration of Hand Movements during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using an MRI-compatible accelerometer attached to the hand with a Velcro strap.
Neural Activation in Primary Motor Cortex during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Neural Activation in Supplementary Motor Cortex during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Total Acceleration of Hand Movements during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using an MRI-compatible accelerometer attached to the hand with a Velcro strap.
Total Acceleration of Hand Movements during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using an MRI-compatible accelerometer attached to the hand with a Velcro strap.
Total Muscle Activation during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using MRI-compatible electromyography sensors placed on the arm.
Total Muscle Activation during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using MRI-compatible electromyography sensors placed on the arm.
Total Muscle Activation during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using MRI-compatible electromyography sensors placed on the arm.
Neural Activation in Primary Motor Cortex during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Total Muscle Activation during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) This measurement will be taken using MRI-compatible electromyography sensors placed on the arm.
Neural Activation in Primary Motor Cortex during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Neural Activation in Primary Motor Cortex during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Neural Activation in Supplementary Motor Cortex during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Neural Activation in Supplementary Motor Cortex during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
Neural Activation in Supplementary Motor Cortex during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Summary beta values representing the level of brain activity will be calculated.
- Secondary Outcome Measures
Name Time Method Electrodermal Activity (EDA) during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) EDA is a procedure for measuring emotional excitement by recording the skin's natural electrical activity. The measurements will be taken using two MRI-compatible sensors attached to the palm of the hand.
Electrodermal Activity (EDA) during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) EDA is a procedure for measuring emotional excitement by recording the skin's natural electrical activity. The measurements will be taken using two MRI-compatible sensors attached to the palm of the hand.
Music Playing Self-Report Questionnaire - Pleasure Score during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's pleasure while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater pleasure.
Neural Activation in Amygdala during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventral Striatum during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Music Playing Self-Report Questionnaire - Cognitive Challenge Score during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's cognitive challenge while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater cognitive challenge.
Electrodermal Activity (EDA) during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) EDA is a procedure for measuring emotional excitement by recording the skin's natural electrical activity. The measurements will be taken using two MRI-compatible sensors attached to the palm of the hand.
Music Playing Self-Report Questionnaire - Pleasure Score during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's pleasure while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater pleasure.
Music Playing Self-Report Questionnaire - Cognitive Challenge Score during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's cognitive challenge while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater cognitive challenge.
Music Playing Self-Report Questionnaire - Pleasure Score during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's pleasure while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater pleasure.
Music Playing Self-Report Questionnaire - Pleasure Score during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's pleasure while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater pleasure.
Music Playing Self-Report Questionnaire - Cognitive Challenge Score during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's cognitive challenge while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater cognitive challenge.
Neural Activation in Amygdala during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventromedial Prefrontal Cortex during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventromedial Prefrontal Cortex during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventromedial Prefrontal Cortex during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventral Striatum during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventral Striatum during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Dorsolateral Prefrontal Cortex during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Electrodermal Activity (EDA) during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) EDA is a procedure for measuring emotional excitement by recording the skin's natural electrical activity. The measurements will be taken using two MRI-compatible sensors attached to the palm of the hand.
Neural Activation in Amygdala during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Amygdala during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Ventromedial Prefrontal Cortex during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Dorsolateral Prefrontal Cortex during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Functional Connectivity with the Ventral Striatum during Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Psychophysiological interactions (PPI) analysis will be used with the seed in the ventral striatum.
Music Playing Self-Report Questionnaire - Cognitive Challenge Score during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) The questionnaire includes 1 question measuring participant's cognitive challenge while performing the music activity. The item is rated on a Likert scale from 1 (low) to 5 (high); higher scores indicate greater cognitive challenge.
Neural Activation in Ventral Striatum during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Neural Activation in Dorsolateral Prefrontal Cortex during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Functional Connectivity with the Ventral Striatum during Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Psychophysiological interactions (PPI) analysis will be used with the seed in the ventral striatum.
Functional Connectivity with the Ventral Striatum during No Improvisation + No Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Psychophysiological interactions (PPI) analysis will be used with the seed in the ventral striatum.
Functional Connectivity with the Ventral Striatum during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI). Psychophysiological interactions (PPI) analysis will be used with the seed in the ventral striatum.
Neural Activation in Dorsolateral Prefrontal Cortex during No Improvisation + Live Accompaniment Task Day 1 (About 3 hours) Measured using functional MRI (fMRI).
Trial Locations
- Locations (1)
NYU Langone Health
🇺🇸New York, New York, United States