Assessing the preventing and therapeutic effect of curcumin mucositis
Phase 3
Recruiting
- Conditions
- oral mucositis.Stomatitis and related lesions
- Registration Number
- IRCT20180416039318N2
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Inclusion criteria were the following: minimum age of 18 years, presence of head and neck cancer, radiationtherapy of 50 Gy or greater, at least 50% of patient’s oral cavity in the field of radiation, and willing to be a part of the study and sign the informed consent..
Exclusion Criteria
Exclusion criteria were the following: the history of previous radiation therapy or chemotherapy, chemotherapy protocol in addition to radiotherapy, any allergy to condiments, especially Turmeric root”, having a pre-existing oral disease such as an active oral infection or an oral ulceration.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of curcumin on severity of mucositis. Timepoint: Before the initiation of radiotherapy and then on days 7, 14, 21, 28, 35 and 42 of the radiotherapy course. Method of measurement: the National Cancer Institute Common Toxicity Criteria version 2 scale (NCI CTC v.2).
- Secondary Outcome Measures
Name Time Method The effect of curcumin on the onset of mucositis. Timepoint: Before the initiation of radiotherapy and then on days 7, 14, 21, 28, 35 and 42 of the radiotherapy course. Method of measurement: the National Cancer Institute Common Toxicity Criteria version 2 scale (NCI CTC v.2).