NCT05254964撤回不适用
Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Strength of connectivity in brain network obtained from MRI neuroimaging data
研究概览
简要总结
Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 19 to 80 years
- •Patients with subacute stroke within 2 weeks of onset
- •First-ever stroke
- •Supratentorial stroke
- •Less than 8 SAFE (shoulder abduction, finger extension) points
- •Less than 35 FMA Upper scores
- •MEP (motor evoked potential) negative
- •Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score
排除标准
- •Difficult to communicate due to severe language impairment.
- •Accompanied by an existing serious neurogenic disease
- •Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
- •If there are difficulties in conducting the research
- •Any patients who are judged by the investigator to be difficult to participate in this study
- •Patients with contraindicated MRI scans
结局指标
主要结局
Strength of connectivity in brain network obtained from MRI neuroimaging data
时间窗: Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks
Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.
次要结局
未报告次要终点
研究者
Yun-Hee Kim
Principal Investigator
Samsung Medical Center
研究点 (2)
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