Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient

Samsung Medical Center1 site in 1 countryFebruary 1, 2022

ConditionsStroke

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke
Sponsor: Samsung Medical Center
Locations: 1
Primary Endpoint: Strength of connectivity in brain network obtained from MRI neuroimaging data
Status: Withdrawn
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.

Registry

clinicaltrials.gov

Start Date

February 1, 2022

End Date

February 28, 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Samsung Medical Center

Responsible Party

Principal Investigator

Yun-Hee Kim

Principal Investigator

Samsung Medical Center

Eligibility Criteria

Inclusion Criteria

•Patients aged 19 to 80 years
•Patients with subacute stroke within 2 weeks of onset
•First-ever stroke
•Supratentorial stroke
•Less than 8 SAFE (shoulder abduction, finger extension) points
•Less than 35 FMA Upper scores
•MEP (motor evoked potential) negative
•Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score

Exclusion Criteria

•Difficult to communicate due to severe language impairment.
•Accompanied by an existing serious neurogenic disease
•Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
•If there are difficulties in conducting the research
•Any patients who are judged by the investigator to be difficult to participate in this study
•Patients with contraindicated MRI scans

Outcomes

Primary Outcomes

Strength of connectivity in brain network obtained from MRI neuroimaging data

Time Frame: Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks

Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.