Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient
Not Applicable
Withdrawn
- Conditions
- Stroke
- Registration Number
- NCT05254964
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Patients aged 19 to 80 years
- Patients with subacute stroke within 2 weeks of onset
- First-ever stroke
- Supratentorial stroke
- Less than 8 SAFE (shoulder abduction, finger extension) points
- Less than 35 FMA Upper scores
- MEP (motor evoked potential) negative
- Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score
Exclusion Criteria
- Difficult to communicate due to severe language impairment.
- Accompanied by an existing serious neurogenic disease
- Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
- If there are difficulties in conducting the research
- Any patients who are judged by the investigator to be difficult to participate in this study
- Patients with contraindicated MRI scans
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Strength of connectivity in brain network obtained from MRI neuroimaging data Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What neuroplasticity mechanisms underlie cognitive rehabilitation's effects on functional networks in subacute stroke?
How does intensive cognitive rehabilitation compare to standard-of-care therapies in restoring motor and language networks post-stroke?
Which biomarkers predict response to intensive cognitive rehabilitation in subacute stroke patients with specific lesion locations?
What adverse events are associated with intensive cognitive rehabilitation in subacute stroke recovery?
Are there combination therapies with pharmacological agents enhancing cognitive rehab outcomes in post-stroke functional network recovery?
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center🇰🇷Seoul, Korea, Republic of