Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study

Not Applicable

Completed

• Conditions: MS (Multiple Sclerosis)
• Interventions: Behavioral: Cog Rehab

• Registration Number: NCT01628276
• Lead Sponsor: Sina Hospital, Iran

Brief Summary

This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance Imaging technique is performed to investigate changes in brain plasticity.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-06-20
• Study First Submitted QC: 2012-06-22
• Study First Posted: 2012-06-26
• Study Start: 2012-07
• Primary Completion: 2013-09
• Study Completion: 2013-10
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-11
• Last Update Posted: 2014-09-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Definitive MS diagnosis
• Right handedness
• EDSS 0-4
• No relapse in past 6 weeks
• Willing to consent and participate in the study

Exclusion Criteria

• Pregnancy
• Left handedness
• Neurologic or psychiatric disorder other than MS

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Rehab Second	Cog Rehab	-
Rehab first	Cog Rehab	-

Primary Outcome Measures

Name	Time	Method
functional connectivity	0, 2nd, 4th Month	Changes in correlation of brain activity in different regions of brain as assessed by Blood Oxygenation Level Dependent (BOLD) signal

Trial Locations

Locations (1)

Sina Hospital; 🇮🇷 Tehran, Iran, Islamic Republic of