Cognitive Rehabilitation Combined to Transcranial Direct Current Stimulation Following Traumatic Brain Injury: Functional Magnetic Resonance Imaging Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Traumatic Brain Injury
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- intergroup difference on cerebral map activation in functional magnetic resonance imaging (N-back task).
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The current study aims to better understand cerebral plasticity mechanisms to optimize non-pharmacological rehabilitation approaches for patients with traumatic brain injury.
Detailed Description
Cognitive impairment following moderate to severe traumatic brain injury are usual. To date, cognitive rehabilitation effects on cerebral plasticity and quality of life remain unproven essentially because of methodological biases. Transcranial Direct Current Stimulation is an innovative technique of noninvasive brain stimulation that showed efficacy in literature. The current study want to better understand cerebral plasticity mechanisms to optimize non-pharmacological rehabilitation approaches for patients with traumatic brain injury. The aim in the present study is to assess the effect of rehabilitation combined with Transcranial Direct Current Stimulation provided to traumatic brain injury patients with cognitive impairment on cerebral plasticity using functional magnetic resonance imaging. Effects of rehabilitation and Transcranial Direct Current Stimulation will be observed on functional magnetic resonance imaging activation maps acquired. Relationship between attentional outcomes measured in the neuropsychological assessment and activation extend will be explored.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Moderate to severe traumatic brain injury
- •more than 3 months since the onset
- •Attentional disorders (PASAT test (score ≤ centile 10) and/or CANTAB test (≤ -2 standard deviation)
- •Women having contraceptive treatment (for the magnetic resonance imaging exam)
Exclusion Criteria
- •inability to undergo magnetic resonance imaging scan
- •No attentional impairment (PASAT ≥ centile10)
- •Severe depression
- •Neurological disease
- •Major cognitive impairment (aphasia, neglect)
- •Drugs addiction
- •Pregnant women and women having no contraceptive treatment
Outcomes
Primary Outcomes
intergroup difference on cerebral map activation in functional magnetic resonance imaging (N-back task).
Time Frame: 12 weeks
Secondary Outcomes
- Intergroup differences in neuropsychological score(12 weeks)
- Intergroup differences in resting activation maps.(12 weeks)
- Correlation between activation extend and attentional outcomes(12 weeks)
- Intergroup differences in diffusion measures(12 weeks)
- Intergroup differences in polymorphisms(12 weeks)