Intestinal permeability 'leaky gut' in critically ill patients

Completed

• Conditions: Critical illness; Increased intestinal permeability; Infection/ sepsis; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Diet and Nutrition - Other diet and nutrition disorders; Infection - Other infectious diseases

• Registration Number: ACTRN12616001101471
• Lead Sponsor: a Trobe University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Adult patients aged greater than or equal to 18 years;
- Patients receiving or suitable for enteral feeding;
- Likely to be admitted to the ICU for greater than or equal to 3 days;
- Likely to require mechanical ventilation for > 24 hours;
- Patients with an indwelling catheter in situ;
- Patients receiving inotropic or vasopressor support at time of enrolment.

Exclusion Criteria

- A past history of gut abnormalities, abdominal surgery within 2 years of ICU admission or malabsorption syndromes;
- Presenting condition or past history of abdominal trauma within 2 years of admission;
- Patients treated with therapeutic hypothermia during admission;
- Patients requiring continuous renal replacement therapy;
- Patients treated with non-steroidal anti-inflammatory drugs;
- Any situation where lactulose or any of the test sugars are used as part of the treatment plan;
- Patients receiving total parenteral nutrition or enteral feeding directly into the small bowel;
- Patients receiving or received chemotherapy or radiotherapy in the past 6 months;
- Pregnancy;
- When participation in the study is not believed to be in the best interest of the patient as determined by the treating physician.

Study & Design

• Study Type: Interventional
• Study Design: Not specified