Gastro-intestinal permeability and intense physical activity (GRINTA)

Completed

• Conditions: gastro-intestinal permeabilty; gut barrier function; intestinal integrity; 10017943

• Registration Number: NL-OMON40654
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

• Male
• Generally healthy
• Recreational athlete with at least two years of cycling experience of at least twice a week
• 18-35 years old
• Meeting criteria of valid max-test
• Body mass index (BMI) 20-25 kg/m2
• Veins suitable for blood sampling at inspection

Exclusion Criteria

• Known symptoms of immune diseases such as diabetes, celiac disease, gastric disease or cystic fibrosis
• Known symptoms of intestinal diseases such as Crohn*s disease, ulcerosis, irritable bowel syndrome or cystic fibrosis
• Smoking
• Use of hard drugs
• Use of specific medicines:
o Chronic use of NSAIDs: aspirin, ibuprofen, etc.
o Drugs for gastric and/or intestinal function
• Participation in other scientific studies
• Blood donation during the last six weeks prior to the start of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the relative increase in intestinal permeability<br /><br>(lactulose/rhamnose ratio) and plasma levels of glutamine and glutamine-derived<br /><br>amino acids.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>As secondary endpoints several markers of gastro-intestinal integrity and<br /><br>inflammation are studied in blood, urine and saliva.</p><br>