A Comparative clinical study of three different ayurvedic formulations along with medicated purgation in Hyperlipidaemia

Not yet recruiting

Conditions: Other hyperlipidemia. Ayurveda Condition: MEDOROGAH,

Registration Number: CTRI/2024/07/071319

Lead Sponsor: Dr Ashwini Patange

Brief Summary: Elevated levels of blood lipids are well documented risk factors for cardiovascular disease and stroke in developed and developing countries. Hyperlipidaemia is second only to hypertension in the list of the 10 most common chronic conditions that were seen. Globally a third of ischemic heart disease is attributed to high cholesterol is estimated to cause 2.6 million deaths.Hyperlipidaemia refers to elevated cholesterol, elevated triglycerides or both. Hyperlipidaemia is a defect often in lipid metabolism or transport. The risk factors commonly observed are unhealthy lifestyles in population such as alcohol consumption, smoking, poor diet and physical inactivity. WHO prevalence of hyperlipidaemia recent studies shows 28.5 million people get affected per year. In India approximately 25-30 % of urban and 15-20 % of rural subjects are suffering hyperlipidaemia.

Medoroga is generally used term for the disorder related to Medodhatu dusthi. Medodusthi is abnormal deposition of Medodhatu in body due to disturbance in metabolism and agnimandya.Medoroga is caused due to unbalanced diet and sedentary habits. As dietary factor includes overeating, frequent eating, excessive madhura, sheeta, guru ahara, atimadypana, behavioural factors like lack of exercise, sleeping in daytime etc. Genetic factors or hereditary factors having significant role in development of Medoroga.

Medodhatu dusthi leads to complex consequential process of Medovruddhi. Medodusthi may happen due to excessive production of Medodhatu (due to dietary, behavioural, Genetic or hereditary factor). This increased Medodhatu causes margavarodha and depletion of other dhatu and aggrevation of vata. This aggravated vata increase false appetite, which leads to over consumption of food and excessive medodhatu production which is sent for circulation. This particular stage is correlated with hyperlipidaemia which has increased circulated lipids in the blood .The lakshanas of medodusthi are Kshudraswasa,Atinidra,Alpabala,Atisweda, Dourgandhya.

After considering nidana, samprapti, lakshana the medications which are having ushna, teekshna, ruksha, laghu guna along with deepana, pachana, kaphahara, medohara and lekhana property will be considered in the treatment.Â—So in this study Panchakola churna , Trayushanadya loha ,Guduchyadi gana ,Vachadi gana .

The drugs selected above will be helpful in avoiding further complications due to hyperlipidaemia. Hence study is entitled as â€œA clinical study to evaluate and compare the effect of Guduchyadi yoga and Vachadi yoga with Trayushanadi loha along with virechana in Medoroga with special reference to Hyperlipidaemia.â€

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Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 120

Inclusion Criteria

1. Patient suffering from Medoroga lakshanas like Kshudraswasa, Nidradhikya, Alpabala, Atisweda, Dourgandhya along with increase level of lipid profile.i.e.Serum total cholesterol level 200mg/dl and above,Serum triglyceride level 150mg/dl and above,Serum HDL level 40mg/dl and below,Serum LDL level 130mg/dl and above,Serum VLDL level 30mg/dl and above 2)Who is fit for ruksha virechana.
3)Age between 20 to 60 years of age group of either sex.

Exclusion Criteria

1)Patient having Hypertension, Diabetes Mellitus, cardiovascular disease, renal disease, acute infective hepatitis, alcoholic hepatitis or cerebral disease.
2)Pregnant and Lactating mother.
3)Patient having disorders like carcinoma anywhere in the body.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To know the effects of intervention on Total cholesterol,serum triglyceride,serum HDL,serum LDL,serum VLDL.	base line-40th day-80th day-108 th day

Secondary Outcome Measures

Name	Time	Method
To evaluate if the hyperlipidemia condition is reversible through virechana and shamana oushadhi.	to standardize the safe and effective ayurvedic line of managment in hyprelipidemia in comparison to established drug in contemporary medicine.

Trial Locations

Locations (2): S V P Rural Ayurvedic Medical College and Hospital Badami
🇮🇳
Bagalkot, KARNATAKA, India
Shri DGM Ayurvedic Medical College and Hospital Gadag
🇮🇳
Gadag, KARNATAKA, India
S V P Rural Ayurvedic Medical College and Hospital Badami
🇮🇳Bagalkot, KARNATAKA, India
Dr Ashwini Patange
Principal investigator
9986842245
ashwinipatange248@gmail.com