Identification of oral cancer genes in pre-cancerous cases by protein-protein interaction analysis.
Not Applicable
- Conditions
- Health Condition 1: R888- Abnormal findings in other body fluids and substances
- Registration Number
- CTRI/2023/07/055137
- Lead Sponsor
- Dr Pooja Sinha
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients above 18 years of age with tobacco habits will be included in the study and will be divided into 2 groups:
Group I: Control group of 74 healthy individuals with tobacco habit
Group II: Case group of 74 OPMD patients with tobacco habits
Exclusion Criteria
Patients with alcohol habit
Pregnant and lactating women.
Subjects with previous treatment for OPMDs.
Subjects with any collagen diseases or immune mediated disorders.
Subjects with history of head and neck tumors, breast cancer and gastric cancer.
Subjects with prior neoplastic surgeries and cancer metastases.
Other diseases such as HIV, Hepatitis, infectious diseases, coronary artery disease, cardiovascular disorders where alteration in salivary biomarkers level can be present.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A. Alternative Hypothesis <br/ ><br>In-silico analysis is a recent method and have significant approach in identifying salivary mRNA based biomarker in OPMD. <br/ ><br>Timepoint: 2 years
- Secondary Outcome Measures
Name Time Method Pre-clinical validation of salivary mRNA biomarkers among patients with tobacco habit and oral potentially malignant patientsTimepoint: 2 years