Oral Microbiota and Oral Status of Adult Patients With Autism Spectrum Disorders (MICAA: MICrobiota Autism Adults)
- Conditions
- Autism Spectrum Disorder
- Interventions
- Other: collection of saliva, gum fluid and/or dental plaque samples
- Registration Number
- NCT05910424
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The goals of this pilot study are to assess the presence of harmful germs for gums and to assess oral health in adults with autism spectrum disorder.
- Detailed Description
Participants or their tutors will fulfill a form with general health information and daily habits.
Investigators will :
* collect saliva, gum fluid and/ or dental plaque to characterise germs
* assess gum health and oral hygiene
* register decays, filled and missing teeth.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
- A person (or legal representative) who has received full information about the organisation of the research and accept to participate and the use of his or her data.
- Adult with autism spectrum disorder, men or women aged between 18 and 60.
- Member of a social security scheme or beneficiary of a medical insurance
- Children under 18 with autism spectrum disorder
- Use of medication or situations that may affect the microbiota (use of antibiotics, probiotics, steroidal or non-steroidal anti-inflammatory drugs in the last 3 months, strict mouth breathing)
- Smoking
- Very lingual position of the teeth hindering clinical assessment of the periodontium
- Patients who have had periodontal treatment for less than 6 months
- Persons covered by articles L. 1121-5 to L. 1121-7 and L1122-2 of the French Public Health Code:
- Pregnant women, women in labour or breast-feeding mothers
- Persons deprived of their liberty by a judicial or administrative decision
- Persons unable to give their consent
- Person under psychiatric care by virtue of articles L. 3212-1 and L. 3213-1 of the Public Health Code
- Minor (not emancipated)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Adults with Autism Spectrum Disorder collection of saliva, gum fluid and/or dental plaque samples * Adults with autism spectrum disorder * Aged between 18 and 60 years old * Dental cares and follow-up in Nancy hospital
- Primary Outcome Measures
Name Time Method Presence of periodontopathogenic bacteria (harmful for gums) Collection on Day 1 Technique used = Polymerase Chain Reaction (PCR) Measure unit = Colony-Forming Unit (CFU)
- Secondary Outcome Measures
Name Time Method Assessment of the periodontal status of patients with Autism Spectrum Disorder Day 1 Index used = the Dutch Periodontal Index 0 = minimum value, better outcome 4 = maximum value, worse outcome
Assessment of the presence of parasites Entamoeba gingivalis subtype 1 (ST1) and subtype 2 (ST2) and Trichomonas tenax Collection on Day 1 Technique = Polymerase Chain Reaction (PCR) Unit = Colony-Forming Unit (CFU)
Assessment of the dental condition Day 1 Dental data will be collected using the Decay-Missing-Filled/Teeth (DMFT) score 0 = minimum value, best outcome 28 = maximum value, worst outcome
Collection of data about lifestyle habits (oral and dental hygiene, diet, activity, etc.) and drug treatments that may influence the clinical parameters observed Before samples collection and clinical examination Data collection via a form fulfilled by the participant or the patient's legal guardian
Assessment of oral hygiene Day 1 Oral hygiene will be assessed using the Silness and Löe plaque index and the lifestyle questionnaire 0 = minimum value, best outcome 3 = maximum value, worst outcome
Trial Locations
- Locations (1)
CHRU Brabois
🇫🇷Vandœuvre-lès-Nancy, France