Dental and oral health, oral microbiota, neurological parameters and incidence of pneumonia in acute stroke patients – a prospective observational study

• Conditions: I61; I62; I63; I64; J13; J14; J15; J16; J17; J18

• Registration Number: DRKS00018063
• Lead Sponsor: niversitätsklinikum Regensburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-07-31
• Study Start: 2019-09-03
• Results First Posted: 2020-11-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

written informed consent
- all investigations planned for the first investigation timepoint achievable within 24 h after inpatient admission at the Stroke-Unit

Exclusion Criteria

- need for endocarditis prophylaxis
- intubation at time of inpatient admission

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Oral Health (DMFT index, Approximal Plaque-Index, max. pocket probing depth for each tooth)<br>- demographic parameters<br>- anamnestic parameters (e.g. medical history)<br>- neurological parameters (e.g. stroke localization)<br>- Investigation time points: Baseline (BL): within 24 h of inpatient admission at the Stroke Unit; 48 h: 48 h after BL; 120 h: 120 h after B

Secondary Outcome Measures

Name	Time	Method
- Mikrobiological analyses (culture-dependent as well as culture-independent by means of 16S rRNA Amplicon Sequencing)<br>- Blood analyses (classic infection markers like CRP)<br>- Investigation time points: Baseline (BL): within 24 h of inpatient admission at the Stroke Unit; 48 h: 48 h after BL; 120 h: 120 h after B