High-flow nasal oxygen (HFNO) vs standard oxygen therapy in patients undergoing transfemoral transcatheter aortic valve implantation (TAVI)
Not Applicable
- Conditions
- Aortic valve diseaseAortic valve stenosisTransfemoral transcatheter aortic valve implantationCardiovascular - Diseases of the vasculature and circulation including the lymphatic system
- Registration Number
- ACTRN12621001080819
- Lead Sponsor
- The Alfred
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Inclusion Criteria
•Informed consent available;
•Adult patients (> 18 years) with signed informed consent with body mass index greater than or equal to 35 kg/m2;
•Elective TAVI procedure; and
•Patients capable of performing a walk test and spirometry
Exclusion Criteria
Exclusion Criteria
•No informed consent available;
•Contraindication to HFNO such as nasal septal defect;
•Uncooperative patient; and
•Need for intubation / conversion to GA during procedure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The partial pressure of oxygen dissolved in the blood (PaO2) taken from an arterial blood gas sample during the procedure[ABG will be taken every 20 minutes or as determined by clinical need]
- Secondary Outcome Measures
Name Time Method The number of desaturations (defined as SpO2 <93% for >10 seconds or SpO2 drop more than 5% from baseline for >10 seconds) at any time during the procedure measured by pulse oximetry.[Duration of the procedure. ];Time spent on the Recovery ward post-procedure measured in hours as taken from medical record[Patients Recovery stay. ];Conversion to general anaesthesia during the procedure as taken from medical record or recorded real time intraoperatively[This will be assessed during the procedure when the decision for conversion to GA is made by the treating doctors. ];Duration of oxygen provision during and post-procedure measured in hours as taken from medical record[Duration of study. ];Time spent in hospital measured in days at discharge as taken from medical record[At hospital discharge];Patient satisfaction[Follow up questioning regarding overall comfort level, respiratory tract dryness, stomach bloating will be assessed prior to discharge, ]