Optic Nerve Head Strain as Biomarker for Glaucoma
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Optic nerve head mechanical strain compared to visual field change over time
研究概览
简要总结
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
详细描述
Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Existing glaucoma patients of Johns Hopkins
排除标准
- •Inability to perform imaging
- •illiterate
- •hearing impaired
- •non-English speakers
研究组 & 干预措施
All subjects
Each subject will be imaged at two different times and eye pressures
干预措施: Images of eye at 2 eye pressures (Device)
结局指标
主要结局
Optic nerve head mechanical strain compared to visual field change over time
时间窗: Approximately 3 years
Strains measured at baseline are tested for association with glaucoma course
次要结局
未报告次要终点