Optic Nerve Head Strain as Biomarker for Glaucoma
- Conditions
- Glaucoma, Open-Angle
- Interventions
- Device: Images of eye at 2 eye pressures
- Registration Number
- NCT06240312
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
- Detailed Description
Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 130
- Existing glaucoma patients of Johns Hopkins
- Inability to perform imaging
- illiterate
- hearing impaired
- non-English speakers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description All subjects Images of eye at 2 eye pressures Each subject will be imaged at two different times and eye pressures
- Primary Outcome Measures
Name Time Method Optic nerve head mechanical strain compared to visual field change over time Approximately 3 years Strains measured at baseline are tested for association with glaucoma course
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States