Clinical study of evaluated the changes of activated microglia in patients of major depressive disorder and bipolar disorder: A PET study
Not Applicable
Recruiting
- Conditions
- major depressive disorder bipolar disorder
- Registration Number
- JPRN-UMIN000026914
- Lead Sponsor
- Hamamatsu University school of medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
-With current history of psychiatric disorder in healthy control -critical state such as suicide attempt -With past or current history of neurological illness (including normal variant such as cave of septum pellucidum detected by MRI) -With past or current history of serious medical illness and/or brain organic diseases -taking medicines such as antiallergic, anticholinergic, antiinflammatory and immunosuppressive agents -History of alcoholics or substance abuse or addiction -In pregnancy or lactation -smoking or having smoking history
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the binding potential of 11C-DPA713 and 11C-DASB in superior and anterior frontal gyrus, orbitofrontal cortex, anterior cingulate gyrus, striatum and hippocampus.
- Secondary Outcome Measures
Name Time Method MRI: T1WI, MRS-MEGAPRESS, rs-fMRI, DTI Cytokine: FGF-2, Eotaxin, G-CSF, GM-CSF, IFN-r, IL-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, IP-10, MCP-1, MIP-1a, MIP-1b, PDGF-BB, RANTES, TNF-a, VEGF, TGF-b1, TGF-b2, TGF-b3 Tryptophan metabolites: DL-Tryptophan, L-5-hydroxy-tryptophan, Serotonin, L-Kynurenine, 5-Hydroxytryptophol, Tryptophol, 5-hydroxyindole-3-acetic acid, indole-3-acetic acid, Anthranilate, Kynurenic Acid, Quinolinecarboxylic Acid, Indole-3-butyric acid, 3-Hydroxykynurenine, 3-hydroxyanthranilate, xanthurenic acid mature BDNF, proBDNF Psychological test: BDI-II, HDRS, YMRS, IES-R, ICG, STAI, SASS, SRRS, CGI-S, WAIS-III, JART Genetic examination: genetic polymorphism analysis and DNA methylation analysis of 5-HTT, GR, BDNF. Global DNA methylation analysis and expression analysis.