Identification of New Biomarkers to Explore Pathology of Renal Tissue and to Predict Outcomes of Diabetic Nephropathy (NExT-DN) Retrospective Study
Not Applicable
- Conditions
- Diabetic kidney disease
- Registration Number
- JPRN-UMIN000046398
- Lead Sponsor
- Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. Renal biopsy cohort 1 People who decline the entry of NExT-DN Study (UMIN000024530). 2. Renal biopsy cohort 2 Patients who withdraw the agreement of previous clinical studies of our department (No: 1009 and No: 1509-005[2063]). 3. Healthy kidney control People who decline the entry of this study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of novel biomerkers and pathophysiological targets in renal tissue, urine, and blood with pathological finding of DKD
- Secondary Outcome Measures
Name Time Method 1. Investigation of clinicopathologic indocators of renal progression in diabetic nephropathy I. eGFR 30-40% decline from baseline II. eGFR decline > 3-5 ml/min/1.73m2/year III. Commencement of dialysis or renal transplantation because of end stage renal disease IV. Development of albuminuric stage 2. Investigation of other major complications of diabetes I.Development of diabetic retinopathy II.CVD event III.Death