Ablation Targets of Scar-related Ventricular Tachycardia Identified by Dynamic Functional Substrate Mapping

Not Applicable

Completed

• Conditions: Tachycardia, Ventricular
• Interventions: Procedure: Radiofrequency ablation

• Registration Number: NCT05086510
• Lead Sponsor: Ain Shams University

Brief Summary

This study aims at comparing the recurrence rates of ventricular tachycardia ablated after being mapped by 2 different techniques.

Detailed Description

The study participants are patients presented with recurrent ventricular tachycardia.

They will be divided into 2 groups in terms of mapping. The first group will use mapping during sinus rhythm to identify late potentials that may be incriminated in the tachycardia circuit.

The other group will undergo mapping during right ventricular extrastimulus pacing to unmask hidden potentials. The identified potentials will be ablated in both groups.

Study Timeline

• Study First Submitted: 2021-09-28
• Study First Submitted QC: 2021-10-07
• Study First Posted: 2021-10-21
• Study Start: 2021-10-28
• Primary Completion: 2023-06-26
• Study Completion: 2023-06-26
• Status Verified: 2023-07
• Results First Submitted: 2023-07-03
• Results First Submitted QC: 2023-07-03
• Last Update Submitted: 2023-07-03
• Results First Posted: 2024-02-20
• Last Update Posted: 2024-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• • Patients with structural heart disease; previous myocardial infarction, left ventricular dilatation/systolic dysfunction, or normal left ventricular diameters/ systolic function with evidence of ventricular scar on contrast enhanced-cardiac magnetic resonance or electroanatomic map.

  • Sustained monomorphic ventricular tachycardia documented by 12-lead ECG or implantable cardioverter defibrillator (electrograms resistant to antiarrhythmic drug treatment or requiring implantable cardioverter defibrillator therapies.

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Exclusion Criteria

• • Patients with ventricular arrhythmias attributed to reversible causes.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Right ventricular extrastimulus pacing group	Radiofrequency ablation	This group will undergo mapping during right ventricular single extrastimulus pacing to identify and thus ablate potentials that might have been masked during sinus rhythm.
Sinus Rhythm	Radiofrequency ablation	This group will undergo mapping during sinus rhythm to identify and ablate late potentials that may be incriminated in the tachycardia circuit.

Primary Outcome Measures

Name	Time	Method
Number of Participants With Recurrence of Ventricular Tachycardia	12 months	Recurrence of ventricular tachycardia implies receiving at least one appropriate implantable cardioverter defibrillator therapy or hospital admission due to symptomatic ventricular tachycardia.

Secondary Outcome Measures

Name	Time	Method
Number of Participants Who Die From Any Cause (All-cause Mortality)	12 months	This includes death from any cause
Number of Participants Who Experience Cardiac Death	12 months	This is defined as unexpected death where a cardiac cause is the most probable etiology

Trial Locations

Locations (1)

AinShams university hospitals; 🇪🇬 Cairo, Egypt