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临床试验/CTRI/2024/03/063571
CTRI/2024/03/063571尚未招募4 期

ULTRASOUND GUIDED AXILLARY APPROACH TO BRACHIAL PLEXUS FOR HAND SURGRIES COMPARISION OF MAGNESIUM SULPHATE AND DEXMEDETOMIDINE AS ADJUVANTS TO ROPIVACAINE

Dr Sunil Chiruvella1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年3月11日最近更新:

试验速览

阶段
4 期
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
Primary objective is to compare onset and

研究概览

简要总结

Axillary brachial plexus blocks are frequently used during hand and forearm procedures. Ropivacaine’s effectiveness is increased when Dexmedetomidine and magnesium sulphate are used for peripheral nerve blocks because they increase the duration of analgesia. This study was aimed to evaluate the effects of. Ropivacaine with magnesium sulphate and Ropivacaine with Dexmedetomidine in the axillary block.Site-specific, efficient, and long-lasting anaesthetic is provided via regional anaesthesia. To enable painless surgery, plexus block is employed as the primary anaesthetic approach. It is also utilised to alleviate chronic pain and post-operative discomfort.Regional anaesthesia is administered during procedures on the upper limbs using a brachial plexus block. Interscalene, supraclavicular, infraclavicular, and axillary are some other techniques. The axillary method to the brachial plexus block is well-liked for its simplicity, dependability, and safety. It is recommended for forearm and hand surgery.With a safer cardiac profile than bupivacaine, ropivacaine is a brand-new long-acting amide local anaesthetic (LA) used for peripheral nerve blocks. It offers both a sensory and a motor blockage. Adjuvant supplementation increases the effectiveness of LA by accelerating the start of action, extending the duration of activity, and providing postoperative analgesia.When administered systemically, magnesium sulphate (MgSO4) has analgesic, antihypertensive, and anaesthetic sparing effects. MgSO4 is now often utilised as an adjuvant to plane blocks, other peripheral nerve blocks, and neuroaxial blocks. However, research on MgSO4’s use as an adjuvant in the axillary block is quite limited.As an adjuvant to LAs, dexmedetomidine is a selective alpha 2 adrenoreceptor agonist. It is believed to shorten the onset and increase the duration of activity, and prolong postoperative analgesia.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Patients undergoing hand surgeries ASA 1 & 2.

排除标准

  • Patients with Co-existing severe cardiovascular respiratory or neurological disorders Patients with any known history of coagulation disorders and inflammatory and infective skin lesions at the site of block Pre-existing neuropathies and allergy to local anaesthetics.

结局指标

主要结局

Primary objective is to compare onset and

时间窗: 5 mins | 10 mins | 15 mins | 30 mins | 1 hour | 2 hours | 6 hours | 12 hours

duration of sensory and motor blockade

时间窗: 5 mins | 10 mins | 15 mins | 30 mins | 1 hour | 2 hours | 6 hours | 12 hours

次要结局

  • Secondary objective is to compare hemodynamic changes, Time for requirement of rescue analgesia and adverse effects in both groups(5 mins)

研究者

发起方
Dr Sunil Chiruvella
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Nagella Jagadeesh Babu

Government Medical College Kadapa

研究点 (1)

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