ULTRASOUND GUIDED AXILLARY APPROACH TO BRACHIAL PLEXUS FOR HAND SURGRIES COMPARISION OF MAGNESIUM SULPHATE AND DEXMEDETOMIDINE AS ADJUVANTS TO ROPIVACAINE
Overview
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Dr Sunil Chiruvella
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Primary objective is to compare onset and
Overview
Brief Summary
Axillary brachial plexus blocks are frequently used during hand and forearm procedures. Ropivacaine’s effectiveness is increased when Dexmedetomidine and magnesium sulphate are used for peripheral nerve blocks because they increase the duration of analgesia. This study was aimed to evaluate the effects of. Ropivacaine with magnesium sulphate and Ropivacaine with Dexmedetomidine in the axillary block.Site-specific, efficient, and long-lasting anaesthetic is provided via regional anaesthesia. To enable painless surgery, plexus block is employed as the primary anaesthetic approach. It is also utilised to alleviate chronic pain and post-operative discomfort.Regional anaesthesia is administered during procedures on the upper limbs using a brachial plexus block. Interscalene, supraclavicular, infraclavicular, and axillary are some other techniques. The axillary method to the brachial plexus block is well-liked for its simplicity, dependability, and safety. It is recommended for forearm and hand surgery.With a safer cardiac profile than bupivacaine, ropivacaine is a brand-new long-acting amide local anaesthetic (LA) used for peripheral nerve blocks. It offers both a sensory and a motor blockage. Adjuvant supplementation increases the effectiveness of LA by accelerating the start of action, extending the duration of activity, and providing postoperative analgesia.When administered systemically, magnesium sulphate (MgSO4) has analgesic, antihypertensive, and anaesthetic sparing effects. MgSO4 is now often utilised as an adjuvant to plane blocks, other peripheral nerve blocks, and neuroaxial blocks. However, research on MgSO4’s use as an adjuvant in the axillary block is quite limited.As an adjuvant to LAs, dexmedetomidine is a selective alpha 2 adrenoreceptor agonist. It is believed to shorten the onset and increase the duration of activity, and prolong postoperative analgesia.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients undergoing hand surgeries ASA 1 & 2.
Exclusion Criteria
- •Patients with Co-existing severe cardiovascular respiratory or neurological disorders Patients with any known history of coagulation disorders and inflammatory and infective skin lesions at the site of block Pre-existing neuropathies and allergy to local anaesthetics.
Outcomes
Primary Outcomes
Primary objective is to compare onset and
Time Frame: 5 mins | 10 mins | 15 mins | 30 mins | 1 hour | 2 hours | 6 hours | 12 hours
duration of sensory and motor blockade
Time Frame: 5 mins | 10 mins | 15 mins | 30 mins | 1 hour | 2 hours | 6 hours | 12 hours
Secondary Outcomes
- Secondary objective is to compare hemodynamic changes, Time for requirement of rescue analgesia and adverse effects in both groups(5 mins)
Investigators
Dr Nagella Jagadeesh Babu
Government Medical College Kadapa