Clinicopathological MRI and CSF correlates of iron accumulation, neurodegeneration and neuroinflammation in Huntington*s disease.
Recruiting
- Conditions
- Huntington's disease1002929910029305
- Registration Number
- NL-OMON54707
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Male and female individuals with an age of 18 years and older; Ability to
undergo MRI scanning; For individuals diagnosed with HD, a positive genetic
test with a CAG repeat expansion of > 36 in the HTT gene is required; For
pre-manifest participants a positive genetic test with a CAG repeat expansion
of >= 40 in the HTT gene is required.
Exclusion Criteria
Contra-indications to MRI scanning and lumbar puncture; Pregnancy; Severe
chorea; Inability to understand the information about the protocol; Severe
physical restrictions.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter are the striatal and cortical QSM measures, in<br /><br>combination with CSF markers for iron, neurodegeneration and neuroinflammation,<br /><br>in een Huntington populatie, in vergelijking tot gezonde controle deelnemers. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Outcome measurement of clinical (neurologisch and psychological) and genetic<br /><br>tests and their correlation with iron accumulation.<br /><br>- Neuroinflammation metabolites, levels and characteristics, as measured with<br /><br>(DW-)MRS iin combinaties with QSM measures en neuroinflammation - biomarkers in<br /><br>CSF, in a Huntington's Disease population, as compared with healthy controls. </p><br>