NCT01769976已完成不适用
Effects of Periodic Fasting Versus Daily Energy Restriction on Metabolic Health
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
The aim of this study is to examine whether periodic fasting improves markers of diabetes risk and cardiovascular health, and will compare this to the effects observed with daily dieting by energy restriction, and also with no change in energy intake.
It is hypothesized that periodic fasting, with or without weight loss, will be as effective as daily energy restriction to improve markers of metabolic health and energy metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI) between 25 and 42 kg/m2
- •weight stable (<5% fluctuation in body weight for the 6 months prior to study entry)
排除标准
- •history of cardiovascular disease, diabetes, major psychiatric disorders, and eating disorders
- •use of prescribed or non-prescribed medications with may affect energy metabolism, gastrointestinal function, body weight, or appetite
- •recent weight changes in 3 months prior to study entry
- •uncontrolled asthma, current fever, upper respiratory infections
- •individuals who regularly perform high intensity exercise (>2 sessions per week)
- •pregnancy, lactation (breast feeding), women who are planning to become pregnant
- •current intake of >140g of alcohol per week
- •current smoker of cigarettes/cigars/marijuana
- •current intake of any illicit substance
- •experience claustrophobia in confined spaces
- •has donated blood within the past 3 months
- •unable to comprehend the study protocol
- •experiences migraines
结局指标
主要结局
Insulin sensitivity
时间窗: 8 weeks
assessed by hyperinsulinemic euglycemic clamp
次要结局
- Cognitive function, hunger, and mood(8 weeks)
- Plasma hormones and adipokines(8 weeks)
- Oxidative stress, stress resistance, and lipid metabolism(8 weeks)
- Energy expenditure(8 weeks)
研究者
A/Prof Leonie Heilbronn
Associate Professor
University of Adelaide
研究点 (2)
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