Do xanthine oxidase inhibitors reduce left ventricular hypertrophy and endothelial dysfunction in normotensive patients with chronic stable angina? - Allopurinol in normotensive patients with left ventricular hypertrophy

• Conditions: eft ventricular hypertrophyNormotensiveChronic stable angina; MedDRA version: 9.1Level: LLTClassification code 10049773Term: Left ventricular hypertrophy; MedDRA version: 9.1Level: LLTClassification code 10049194Term: Stable angina pectoris; MedDRA version: 9.1Level: LLTClassification code 10005754Term: Blood pressure normal

• Registration Number: EUCTR2008-008479-32-GB
• Lead Sponsor: niversity of Dundee

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01-15
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

Normotensive patients (SBP<150/90)
Left ventricular hypertrophy on echo
Stable angina
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Suffers from gout
Already on allopurinol treatment
Previous adverse reaction to allopurinol
Patient currently on azathioprine
Renal dysfunction (eGFR < 60ml/min)
Heart failure or LVEF <45%
Contraindications to MRI such as metal implants in body and claustraphobia
Cancer or lifethreatening illness
Pregnancy or breastfeeding
Unable to give informed consent

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Secondary Objective: Does Allopurinol reduce endothelial dysfunction in normotensive patients with stable angina?;Primary end point(s): Left ventricular hypertrophy regression on cardiac MRI<br><br>To see if allopurinol reduces endothelial dysfunction as assessed by flow mediated dilatation (FMD);Main Objective: Does Allopurinol reduce left ventricular hypertrophy in normotensive patients with stable angina?