A study to compare the effects of Midazolam, Dexmedetomidine and Ketamine premedication on the recovery profile after anaesthesia
- Conditions
- Measurement and Monitoring,
- Registration Number
- CTRI/2021/07/034859
- Lead Sponsor
- Dr Phindariiaki Wankhar
- Brief Summary
A randomized double-blinded clinical trial to study the effects of 0.04 mg/kg of IV Midazolam, 0.05 mcg/kg of IV Dexmedetomidine and 0.25 mg/kg of IV Ketamine pre-medication in the recovery profile in 99 patients aged 18 to 60 years with ASA I and II undergoing major surgeries of less than 3 hours duration under balanced anaesthesia. The study will be conducted in the Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur. The study drug will be given over 10 minutes before induction with Propofol. Post- operatively, recovery profile will be assessed in terms of emergence time, recovery time based on Modified Aldrete Score, time to first rescue analgesia based on Visual Analogue Scale (VAS), any episode of nausea/vomiting during the first one hour, any episode of dreaming, awareness on questioning post- operatively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 99
ASA Grade I and II Undergoing major surgeries of duration less than 3 hours.
- Hepatic, renal, neurological, cardiovascular and respiratory illnesses 2.
- Allergy to any study drug 3.
- Anticipated difficult airway.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recovery profile after balanced anaesthesia 1 hour
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Regional Institute of Medical Sciences
🇮🇳West, MANIPUR, India
Regional Institute of Medical Sciences🇮🇳West, MANIPUR, IndiaDr Phindariiaki WankharPrincipal investigator8413078481phindi07@gmail.com