Effect of pomegranate supplement on Rheumatoid Arthritis patients

Not Applicable

• Conditions: Condition 1: Rheumatoid arthritis. Condition 2: Rheumatoid arthritis.; Other rheumatoid arthritis; Seropositive rheumatoid arthritis

• Registration Number: IRCT201202183236N2
• Lead Sponsor: Vice chancellor for research OF Shiraz university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Rheumatoid arthritis patients which their disease diagnosed according to the revised American Rheumatism Association criteria, ages between 18-65 years old, RA patients who don’t have enough clinical and laboratory response to conventional disease modifying anti rheumatic drugs (Methotrexate, Hydroxychloroquine, Sulphasalazine, and prednisolone), No drug type and dose fluctuation since 1 month prior to the study and during intervention period.
Exclusion criteria: Presence of Chronic disease such as diabetes, cardiovascular, hepatic, kidney, gastrointestinal diseases, and severe infection, smoking, Alcohol consumption, use of supplements (antioxidants, multivitamins,...), patients with known allergy and food intolerance.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disease activity. Timepoint: Before and 2 months after intervention. Method of measurement: DAS 28.;Disability and Pain scales. Timepoint: Before and 2 months after intervention. Method of measurement: health Assessment Questionnaire for Rheumatoid Arthritis patients.;Duration of morning stiffness. Timepoint: Before and 2 months after intervention. Method of measurement: Taking history and Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Glutathione peroxidase. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit.;MDA. Timepoint: Before and 2 months after intervention. Method of measurement: Spectrophotometry.;CRP. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit.;ESR. Timepoint: Before and 2 months after intervention. Method of measurement: Westergren.;MMP3. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit.