Prospective, Randomized, Comparative Study on the Efficacy of one day versus 3 days of intravenous Amikacin(15mg/Kg) as prophylaxis in patients undergoing transurethral resection of the Prostate

In urological practice transurethral resection of prostate (TURP) is the most commonly performed operation. The aim of antibiotic prophylaxis is to reduce the bacteriuria rate and thereby reduce the complications associated with it. This is a prospective, randomized comparative study conducted in the department of Urology at Christian Medical College, Vellore. Patients with a sterile preoperative urine culture (CFU< 104/ml) undergoing TURP will be included. Patients will receive either one day or 3 days of intravenous Amikacin(15mg/Kg). Clinical examination and urine culture of the patients will be performed pre operatively and 5-7 days postoperatively. Post-operative bacteriuria rate (CFU> 104/ml) will be considered as significant. A follow up at 4 weeks will be done either through an OPD visit or a telephonic interview. Postoperative bacteriuria, symptomatic UTI and development of sepsis and other complications will be recorded. The efficacy (non inferiority) of single versus 3 doses of intravenous Amikacin will be assessed.