nderstanding of energy metabolism in patients with chronic liver disease (CLD) and an interventional study to assess the clinical effect of measured calorie delivery using Indirect Calorimeter versus estimated calorie delivery in ventilated patients with liver cirrhosis admitted in the IC
- Conditions
- Health Condition 1: K721- Chronic hepatic failure
- Registration Number
- CTRI/2020/07/026845
- Lead Sponsor
- ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Eligible for enteral feeding with a functional gastrointestinal tract (with or without SPN)
2.Mechanically ventilated patients expected to be on ventilator support for at least 5 days
3.Expected length of ICU stay greater than 3 days
4.Initiated on nutrition support (parenteral/or enteral nutrition)
5.The diagnosis documented by physician within one day of ICU admit
6. Signed informed consent
1.Active upper gastrointestinal bleeding
2.If there are conditions which precluded IC, such as an FiO2 >60 %, failure to cooperate, agitation, seizure activity, spasticity, or positive end-expiratory pressure (PEEP) >10 mmHg.
3. Pregnant women
4. Refused to consent/ inability to obtain informed consent
5.Known long standing diabetic
6. If there is any evidence of medical/surgical instability
7. Hepatocellular carcinoma Extrahepatic malignancies
8. Those receiving total parenteral (TPN)
9. With persistent gastrointestinal dysfunction and ileus
10. Readmitted to the ICU
11. Terminally ill patients on high inotropic (triple) support
12. Acute liver failure
13. If there is any evidence of medical/surgical instability
14. If patients are taking any portion of nutrition by mouth
15. Patient on CRRT- continuous renal replacement therapy for more than 48 hours oICU admission
16. Severe co morbidities such as CKD requiring maintenance dialysis, COPD ancardiac pathologies.
17.Moribund patient with likely survival <24 hours
18. Patients enrolled in other drug trials
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method