Effect of a multimodal fasting program (Optifast®) on periodontal parameters

Not Applicable

Recruiting

• Conditions: K05.3; K05.1; Chronic periodontitis; Chronic gingivitis

• Registration Number: DRKS00031695
• Lead Sponsor: niversitätsklinik Heidelberg, MZK-Klinik, Abteilung für Zahnerhaltungskunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

Ability to give consent
- Planned participation in the Optifast® program, inclusion criterion BMI =30kg/m2.

Exclusion Criteria

- Antibiotic intake in the last 6 months
- Use of medications that may affect (gingival) inflammation
- Presence of severe general diseases including diseases with high risk of endocarditis, immunosuppression and present infectious diseases (HIV)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relative proportion of sites with periodontal bleeding on brobing, three and six months after baseline

Secondary Outcome Measures

Name	Time	Method
Change in periodontal probing depths, clinical attachment loss, gingival bleeding, subgingival microbiome, gut microbiome, gingival crevicular fluid flow rate, cytokine composition in gingival crevicular fluid, other standard laboratory parameters, levels of volatile sulfur compounds in breath, quantity of tongue coating - all after three and six months. In addition, the change of dietary habits after six months.