Frequency and Predictors of Recurrent SBP in Cirrhotic Patients in Al Rajhi University Hospital

Not yet recruiting

• Conditions: Spontaneous Bacterial Peritonitis

• Registration Number: NCT06778616
• Lead Sponsor: Assiut University

Brief Summary

* Assess the frequency of recurrent SBP in ascitic cirrhotic patients.

* Determine the predictive factors of recurrence after the first episode of SBP in ascitic cirrhotic patients

Detailed Description

Spontaneous bacterial peritonitis (SBP) is a common complication in cirrhotic patients. The prevalence of SBP in hospitalized patients and the mortality rate were reported to be 10%-30% and 30%-50%, respectively.

SBP has been considered a life-threatening infection that requires a prompt diagnosis and treatment.

Study Timeline

• Study First Submitted: 2024-09-09
• Status Verified: 2025-01
• Study First Submitted QC: 2025-01-12
• Last Update Submitted: 2025-01-12
• Study First Posted: 2025-01-16
• Last Update Posted: 2025-01-16
• Study Start: 2025-02
• Primary Completion: 2025-10
• Study Completion: 2025-11

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• Any cirrhotic patient above the age of 18 years old of both sexes, having a first episode of SBP will be included in our study.

  1. The diagnosis of cirrhosis was based on clinical manifestation (ascites, splenomegaly, lower limb edema and/or esophageal varices by upper gastrointestinal endoscopy), laboratory findings and radiological (abdominal ultrasonography), or liver histology.
  2. The diagnosis of SBP was based on a neutrophil cell count of 250 cell or more per mm3 with or without culture positivity of ascitic fluid, in the absence of hemorrhagic ascites and secondary peritonitis.

Exclusion Criteria

• Any patient with one or more of the following criteria will be excluded:

  1. Patients with bacterial ascites defined by a positive culture of ascitic fluid associated with a neutrophil cell count less than 250 cell per mm3 in the ascitic fluid.
  2. Patients presenting with empyema or bacterial peritonitis secondary to an intra-abdominal organ perforation or surgical operation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency and Predictors of Recurrent Spontaneous Bacterial Peritonitis in Cirrhotic Patients in Al Rajhi University Hospital.	One year	Determine the frequency of recurrent SBP after its management within one year

Secondary Outcome Measures

Name	Time	Method
Predictors of recurrent SBP	One year	Determining risk factors of recurrent SBP

Trial Locations

Locations (2)

Assiut Faculty of Medicine; 🇪🇬 Assiut, Egypt

Assiut University; 🇪🇬 Assiut, Egypt