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临床试验/CTRI/2025/10/096175
CTRI/2025/10/096175尚未招募不适用

From Lesion to Resolution: A CBCT-Based retrospective study comparing bioactive materials for Non-Surgical Root Canal Therapy

Mohil Kale1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年10月30日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
Significant difference between all three materials

研究概览

简要总结

Aim:-

To evaluate the effect of non-surgical healing on large periapical lesions of teeth using bioactive materials with the aid of CBCT scans after a follow up period of 6 months and 1 year.

Materials and method:-

A total of 40 teeth were taken for this retrospective study with single or multirooted teeth and periapical pathology of more than 4mm in diameter present with pre-operative and follow-up CBCTs available. All the cases considered underwent endodontic treatment using one of three bioactive materials (MTA, Biodentine, Bioceramics). Assessment of healing was done based on radiographic CBCT scans and CBCT-PAI criteria. The teeth were divided into healing, healed or diseased based on changes in the CBCT PAI score after 6 months and 1 year. All the data was recorded in a tabular form and sent for statistical analysis using chi-square test, t-test and Friedmann’s test.

Results:-

There was no statistically significant difference in age-wise, gender-wise or arch-wise distribution. Whilst there was a statistically significant difference in individual teeth after 6 months and 1 year, with maxillary incisors showing the highest percentage of healing after 1 year. Increase in healed cases was also seen across all groups after 1 year. No significant difference was seen between the use of the three bioactive materials

Conclusion:-

Amongst all the teeth assessed, single rooted maxillary teeth showed the highest amount of healing. All three Bioactive materials showed a favourable outcome for the treatment regardless of the material used

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Patients with teeth having periapical pathology of more than 4 mm in diameter, having pre-operative and follow up CBCTs available, presence of swelling or sinus tract and teeth with appropriate hard tissue structure left to be restored.

排除标准

  • Cases needing endodontic retreatment, teeth with fractures or perforations and endo-perio lesion.

结局指标

主要结局

Significant difference between all three materials

时间窗: after 6 months and one year

次要结局

  • No significant difference between all three materials (MTA, Biodentine, Bioceramics)(after 6 months & one year)

研究者

发起方
Mohil Kale
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Mohil Kale

College Of Dental Sciences And Research Center

研究点 (1)

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