Vitamin and Unsaturated Fatty Acid Supplements in Healthy and Uveitis Human Subjects

Not Applicable

Completed

• Conditions: Uveitis; Healthy; Autoimmune Diseases
• Interventions: Dietary Supplement: Fatty acid mixture; Dietary Supplement: Vitamin A treatment; Dietary Supplement: Monounsaturated fatty acid mixture; Dietary Supplement: Polyunsaturated fatty acid mixture

• Registration Number: NCT06491979
• Lead Sponsor: Tianjin Medical University

Brief Summary

The goal of this clinical trial is to learn if dietary supplements containing vitamin and unsaturated fatty acid works to intervene T cell inflammatory factor expression in patients with uveitis and healthy subjects in adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-07-01
• Study First Submitted QC: 2024-07-01
• Study First Posted: 2024-07-09
• Study Start: 2024-07-15
• Primary Completion: 2024-08-17
• Study Completion: 2024-10-31
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-05
• Last Update Posted: 2024-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• healthy or with uveitis volunteers age 19-65 years.

Exclusion Criteria

• abnormal blood glucose, blood pressure, blood lipids, or other systemic diseases should not participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Fatty acid mixture	Fatty acid mixture	-
Vitamin A treatment	Vitamin A treatment	-
Monounsaturated fatty acid mixture	Monounsaturated fatty acid mixture	-
Polyunsaturated fatty acid mixture	Polyunsaturated fatty acid mixture	-

Primary Outcome Measures

Name	Time	Method
Inflammatory factors-Interleukin-17A (IL-17A)	3 weeks	Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Interleukin-17A (IL-17A) -producing cells in CD4+ T cells and CD8+ T cells
Inflammatory factors-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)	3 weeks	Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) -producing cells in CD4+ T cells and CD8+ T cells
Inflammatory factors-Interferon gamma (IFN-γ)	3 weeks	Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to detect the ratio of Interferon gamma (IFN-γ) -producing cells in CD4+ T cells and CD8+ T cells

Secondary Outcome Measures

Name	Time	Method
Cytokine levels-Interferon gamma (IFN-γ)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interferon gamma (IFN-γ) in plasma
Cytokine levels-Interleukin-2 (IL-2)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interleukin-2 (IL-2) in plasma
Cytokine levels-Interleukin-10 (IL-10)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interleukin-10 (IL-10) in plasma
Cytokine levels-Interleukin-17A (IL-17A)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interleukin-17A (IL-17A) in plasma
Cytokine levels-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in plasma
Cytokine levels-Interleukin-4 (IL-4)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interleukin-4 (IL-4) in plasma
Cytokine levels-Interleukin-9 (IL-9)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Interleukin-9 (IL-9) in plasma
Cytokine levels-Tumor Necrosis Factor alpha (TNF-α)	3 weeks	Analysis of cytokine levels in blood. Detect the concention of Tumor Necrosis Factor alpha (TNF-α) in plasma

Trial Locations

Locations (1)

Tianjin Medical University Eye Hospital; 🇨🇳 Tianjin, Tianjin, China