To test if a A new investigation called Cardiopulmonary testing can be used as an early indicator of heart disease caused by chemotherapy in breast cancer patients and to compare the results with post operative recovery in patients proceeding for surgery without chemotherapy.
- Conditions
- Health Condition 1: null- Patients with breast cancer
- Registration Number
- CTRI/2018/07/014736
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Carcinoma breast patients willing to take part in the study
1.Unstable cardiac status (Acute myocardial infarction 3â??5 days, unstable angina, moderate stenoticvalvular heart disease, uncontrolled arrhythmias, syncope, active endocarditis,acute myocarditis or pericarditis,hypertrophic cardiomyopathy, uncontrolled heart failure)
2.Significant pulmonary hypertension
3.Acute pulmonary embolus or pulmonary infarction
4.Electrolyte abnormalities
5.Thrombosis of lower extremities
6.Orthopedic impairment that compromises exercise performance
7.Uncontrolled asthma
8.Pulmonary oedema
9.Room air desaturation at rest < 85%
10.Respiratory failure
11.Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise(i.e. infection, renal failure, thyrotoxicosis)
12.Mental impairment leading to inability to cooperate
13.Patient refusal
14.Age < 18 years and > 72 years
15.Pregnant patients
16.Emergency surgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the changes with respect to cardiopulmonary dysfunction in Cardiopulmonary exercise testing variables in carcinoma breast patients pre chemotherapy and post neo-adjuvant chemotherapy.Timepoint: To study the changes with respect to cardiopulmonary dysfunction in Cardiopulmonary exercise testing variables in carcinoma breast patients pre chemotherapy and post neo-adjuvant chemotherapy.
- Secondary Outcome Measures
Name Time Method To assess the difference in functional recovery after the surgery in breast carcinoma patients undergoing upfront surgery Vs breast cancer patients undergoing surgery following neoadjuvant chemotherapy.Timepoint: 6 weeks after surgery