Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise

Completed

• Conditions: Osteoporosis; Sarcopenia

• Registration Number: NCT04444661
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort.

The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-10
• Study First Submitted: 2020-06-19
• Study First Submitted QC: 2020-06-22
• Study First Posted: 2020-06-23
• Primary Completion: 2020-11-11
• Study Completion: 2020-12-31
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-27
• Last Update Posted: 2021-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 21

Inclusion Criteria

• participants of the FrOST study (NCT03453463)

Exclusion Criteria

• medication and diseases with potential impact on study outcomes during the last 26 weeks.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SMI	Change from Baseline to 26 weeks	Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry

Secondary Outcome Measures

Name	Time	Method
Maximum hip-/leg extensor strength	Change from Baseline to 26 weeks	Maximum hip-/leg extensor strength as determined by an isokinetic leg press
BMD-hip	Change from Baseline to 26 weeks	Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry
Metabolic Syndrome Z-Score	Change from Baseline to 26 weeks	Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure)
BMD-LS	Change from Baseline to 26 weeks	Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry
Fat infiltration thigh muscles	Change from Baseline to 26 weeks	Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Fat infiltration para-vertebral muscles	Change from Baseline to 26 weeks	Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Self rated physical performance	Change from Baseline to 26 weeks	Late-Life Function and Disability Index of McAuley et al.
Sarcopenia-Z-Score	Change from Baseline to 26 weeks	Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity)

Trial Locations

Locations (1)

Institute of Medical Physics, Friedrich Alexander University Erlangen-Nürnberg; 🇩🇪 Erlangen, Bavaria, Germany