A comparative study of the efficacy of intravenous paracetamol and dexmedetomidine alone and in combination on peri-operative haemodynamics and post-operative analgesia for patients undergoing laparoscopic cholecystectomy under general anesthesia.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Dexmedetomidine and Paracetamol combination is more effective in maintaining the hemodynamic responses and intraoperative hemodynamic variables in laparoscopic cholecystectomy surgery than individual drugs.
研究概览
简要总结
This study is prospective, double blinded, randomised controlled study comparing the efficacy of dexmedetomidine and paracetamol alone and in combination on perioperative haemodynamics and postoperative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Laparoscopic surgery a challenge to the anaesthesiologist as it is accompanied with haemodynamic instability and postoperative pain, in this study we are looking for better drug or combination of drugs for attenuating these complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Consent to participate in the study 2.Patients scheduled for laparoscopic cholecystectomy 3.American society of anaesthesiology grade 1 and 2.
排除标准
- •1.Uncooperative patient/ not able to understand pain assessment test 2.Pregnant and lactating women 3.History of any significant pulmonary, cardiovascular, neurological, hepatorenal, pshyciatric or metabolic disease.
- •4.Bleeding diathesis.
- •5.History of previous allergy to paracetamol.
结局指标
主要结局
Dexmedetomidine and Paracetamol combination is more effective in maintaining the hemodynamic responses and intraoperative hemodynamic variables in laparoscopic cholecystectomy surgery than individual drugs.
时间窗: baseline, 24hours
次要结局
- Postoperative pain is minimal with combination group(24hours)