A clinical trial to compare the effects of two drugs, dexmedetomidine , a drug used in treatment of raised blood pressure and paracetamol , a drug used for pain relief in patients undergoing laparoscopic cholecystectomy.

Phase 4

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/10/046735
• Lead Sponsor: DrGadde Venkata Harshitha

Brief Summary

This study is prospective, double blinded, randomised controlled study comparing the efficacy of dexmedetomidine and paracetamol  alone and in combination on perioperative haemodynamics  and postoperative analgesia in patients undergoing laparoscopic cholecystectomy under general anesthesia. Laparoscopic surgery a challenge to the anaesthesiologist as it is accompanied with haemodynamic instability and postoperative pain, in this study we are looking for better drug or combination of drugs for attenuating these complications.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-10-21
• Study Start: 2022-10-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

1.Consent to participate in the study 2.Patients scheduled for laparoscopic cholecystectomy 3.American society of anaesthesiology grade 1 and 2.

Exclusion Criteria

• 1.Uncooperative patient/ not able to understand pain assessment test 2.Pregnant and lactating women 3.History of any significant pulmonary, cardiovascular, neurological, hepatorenal, pshyciatric or metabolic disease.
• 4.Bleeding diathesis.
• 5.History of previous allergy to paracetamol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dexmedetomidine and Paracetamol combination is more effective in maintaining the hemodynamic responses and intraoperative hemodynamic variables in laparoscopic cholecystectomy surgery than individual drugs.	baseline, 24hours

Secondary Outcome Measures

Name	Time	Method
Postoperative pain is minimal with combination group	24hours

Trial Locations

Locations (1)

J.A group of hospitals, Gajra raja medical college; 🇮🇳 Gwalior, MADHYA PRADESH, India

J.A group of hospitals, Gajra raja medical college

🇮🇳Gwalior, MADHYA PRADESH, India

Gadde venkata Harshitha

Principal investigator

7997899898

harshi.gadde333@gmail.com