The neurobiological basis of bias and disengagement; Two neurotransmitter mechanisms implicated in visual spatial attention.
Withdrawn
- Conditions
- Geen aandoeninggeneesmiddelen worden gebruikt om selectief aandachtssystemen te inhiberen dmv noradrenergisch dan wel cholinergisch antagonismeNeurobiology of (visuospatial) attention
- Registration Number
- NL-OMON33564
- Lead Sponsor
- niversiteit Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
Passing the physical/medical evaluation (in which cardiovascular functioning and blood pressure is evaluated) is a prerequisite.
Exclusion Criteria
Diagnosis of psychopathology.
Current drug use
Low blood pressure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Behavioural measures<br /><br><br /><br>In the VSC paradigm: the validity effect in ms (RT valid cued target - RT<br /><br>invalid cued target).<br /><br>A larger validity effect reflects either more bias, or less disengagement.<br /><br><br /><br>In the stop task paradigm: the stop signal reaction time (SSRT); SSRT reflects<br /><br>inhibition and related disengagement.<br /><br><br /><br>Neurophysiological (ERP) endparameters in the VSC:<br /><br><br /><br>1) Parietal cue ERP components (ADAN + LDAP), related to bias.<br /><br>2) P1 valid cued target ERP, related to bias.<br /><br>3) LPD invalidly cued target ERP, related to disengagement.<br /><br><br /><br>Neurophysiological (ERP) endparameters in the stop task:<br /><br><br /><br>1) N2 stop signal ERP, related to disengagement.<br /><br>2) LPD stop signal ERP, related to disengagement.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>