Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment (MCI)
- Sponsor
- National Research Center for Rehabilitation Technical Aids
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Change in Cognitive function (MoCA)
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.
Detailed Description
Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.
Investigators
Pengxu Wei
Director
National Research Center for Rehabilitation Technical Aids
Eligibility Criteria
Inclusion Criteria
- •Adults being able to walk at least a block, and
- •Adults with subjective cognitive decline (SCD), or
- •Adults with mild cognitive impairment (MCI), or
- •Adults with normal cognitive function
Exclusion Criteria
- •Clinical diagnosis of dementia
- •Adults who cannot follow the protocal
Outcomes
Primary Outcomes
Change in Cognitive function (MoCA)
Time Frame: Change from Baseline Cognitive test results at 3 months.
The Montreal Cognitive Assessment test is used to assess cognitive function of participants.
Change in Cognitive function (AD8)
Time Frame: Change from Baseline Cognitive test results at 3 months.
The AD8 test is used to assess cognitive function of participants.
Change in Cognitive function (CDR)
Time Frame: Change from Baseline Cognitive test results at 3 months.
The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants.
Change in Cognitive function (SCD-9)
Time Frame: Change from Baseline Cognitive test results at 3 months.
The SCD-9 questionnaire is used to assess cognitive function of participants.
Secondary Outcomes
- Change in Physical capacity (TUG)(Change from Baseline physical capacity test results at 3 months.)
- Change in Physical capacity (chair standing)(Change from Baseline physical capacity test results at 3 months.)