Impact of medical history on the morphologic, histological and molecular-genetic characteristics of intracranial aneurysms

• Conditions: I67.1; I60.9; Cerebral aneurysm, nonruptured; Subarachnoid haemorrhage, unspecified

• Registration Number: DRKS00027349
• Lead Sponsor: eurosurgeon

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1) Angiographic detection of an intracranial aneurysm.
2) Microsurgical clipping of the aneurysm with intraoperative sampling from the aneurysm wall.

Exclusion Criteria

Missing consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoints of this exploratory prospective study are the correlations between immunohistological expression profile in IA wall with: <br>1. the sociodemographic and medical history of the patients;<br>2. the radiographic characteristics of the IA (size, morphology, multiple IA, etc.);<br>3. the rupture status of the IA at initial diagnosis.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints include correlations between:<br>1. histologic markers and radiologic characteristics on diagnostic imaging;<br>2. radiological characteristics and rupture status;<br>3. sociomedical history and rupture status.