Clinical characteristics, natural history, health care measures, and the frequency of genetic variants in the genes of SOD1, C9orf72, FUS and TARDBP in patients with sporadic and familial amyotrophic lateral sclerosis (ALS)
Recruiting
- Conditions
- G12.2Motor neuron disease
- Registration Number
- DRKS00032090
- Lead Sponsor
- Ambulanzpartner Soziotechnologie APST GmbH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria
ALS, including classical ALS, Progressive Muscle atrophy (PMA) or Primary Lateral Sclerosis (PLS)
Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (PHI) under national and local subject privacy regulations
Age of 18 years old at the time of informed consent
Exclusion Criteria
Inability to provide patient directives about the notification of individual study results on genetic variants of SOD1, C9orf72, FUS and TARDBP
Inability to comply with study requirements
Unspecified reasons that, in the opinion of the site investigator, perceive the subject as unsuitable for enrollment
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •To identify the frequency of genetic variants in the genes of SOD1, C9orf72, FUS and TARDBP in patients with sALS and fALS-Study subjects will have up to 3 assessments, with a 4-month interval for approximately one year.
- Secondary Outcome Measures
Name Time Method •To investigate the demographic and social characteristics<br>•To investigate the family history for ALS or FTD<br>•To investigate the clinical classification, functional deficits and progression