Effects of exercise on nerve action that controls the muscle fibers and blood vessels of patients with pre-dialysis chronic kidney disease

Not Applicable

• Conditions: Chronic Kidney Disease, post-exercise hypotension, Sympathetic Nervous System; C10.177.575.600.537; C12.777.419.780.750; A08.800.050.800

• Registration Number: RBR-6ffm72
• Lead Sponsor: Faculdade de Medicina da Universidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-05
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

21 Men and women; between 30 and 60 years; Without participation in structured physical activity; not obese; nondiabetic. They were divided into 2 groups: Control (normotensive patients) and Chronic renal disease, stage III (creatinine clearance 30 to 60 mL / min / 1.73m2, hypertensive controlled in use of angiotensin converting enzyme inhibitors or Angiotensin receptor antagonists).

Exclusion Criteria

Patients with anemia; in the chronic kidney disease group, we excluded patients who were taking beta-blockers and sympatholytic. And also with creatinine clearance <30 and> 60 mL / min / 1.73m2.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The maintenance of 24h proteinuria values in patients with CKD - stage III, after an aerobic exercise session, compared to the rest session.;<br>Outcome found: after the exercise session, patients of kidney disease and control group showed reduction in blood pressure, sympathetic nerve activity and peripheral vascular resistance, compared to the rest session.;The reduction of sympathetic nerve activity and blood pressure in patients with CKD (chronic kidney disease) - stage III after an aerobic exercise session compared to the values of rest session and to the control group.

Secondary Outcome Measures

Name	Time	Method
After the exercise session, patients of kidney disease group showed an increase in forearm blood flow and heart rate,compared to the rest session.;There were no increases in proteinuria in patients with kidney disease, after an aerobic exercise session, compared to the rest session.